卵巢低反应患者高孕激素状态下促排卵的有效性研究  

The effect of progestin-primed ovarian stimulation in women with poor ovarian response

作　　者：刘尧芳 廖运梅 王芳 黄桂英 毛熙光 

机构地区：[1]西南医科大学附属医院生殖部,泸州646000

出　　处：《现代妇产科进展》2016年第11期846-848,共3页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨高孕激素状态下促排卵对卵巢低反应患者LH水平的影响及促排卵效果。方法:将100例存在卵巢低反应的患者随机分为观察组、对照组,每组各50例。观察组采用醋酸甲羟孕酮联合注射用尿促性素促排卵,对照组采用超短方案。分析观察组促排卵过程中LH水平的变化,比较两组患者的获卵数、成熟卵数、优质胚胎数及行冻融胚胎移植(FET)后的妊娠率等。结果:观察组在促排卵过程中未监测到LH峰;两组的获卵数、成熟卵数、受精数等比较,差异均无统计学意义(P>0.05),两组行FET后的妊娠率、胚胎种植率比较,差异无统计学意义(P>0.05)。结论:高孕激素状态下促排卵能有效抑制LH峰,对于卵巢低反应者能达到较好的促排卵效果,可作为一种备选方法。Objective： To investigate the impact of progestin-primed ovarian stimulation on luteinizing hormone（ LH） and the efficacy of ovulation induction in patients with poor ovarian response. Methods： 100 patients with poor ovarian response were divided into two groups. In observation group（ 50 patients）,medroxyprogesterone and menotrophin were applied for ovulation induction. While ultra-short program was used in control group. LH level in observation group was recorded. And aim to test retrieved oocyte number,mature oocytes,high quality embryo number and pregnancy rate following FET etc. Results： No peak value of LH was found in observation group. There was no significant difference of retrieved oocyte number,mature oocytes,fertilization number and pregnancy rate following FET between two groups（ P 〉0. 05）.Conclusion： Progestin-primed ovarian stimulation could significantly inhibit the peak value of LH,and served as a good alternative in patients with poor ovarian response.

关 键 词：卵巢低反应 醋酸甲羟孕酮 IVF/ICSI-ET 

分 类 号：R321.33[医药卫生—人体解剖和组织胚胎学]