血小板血型抗体与妊娠次数及复发性流产关系的研究  

Relationship between Platelet-specific Alloantibody and Gravidity or Recurrent Spontaneous Abortion

作　　者：汤洁[1] 赵莹莹[1] 魏威[1] 闫素文[1] 张宁[1] 

机构地区：[1]中国人民解放军第202医院优生优育研究所,辽宁沈阳110003

出　　处：《沈阳医学院学报》2016年第6期445-446,450,共3页Journal of Shenyang Medical College

基　　金：军队临床高新技术重大项目(No.2010gxjs003)

摘　　要：目的：检测血小板血型抗体在孕妇血清中的表达情况，分析其与妊娠次数及复发性流产的关系。方法：选择2015年4月至12月，在解放军第202医院优生优育研究所进行产前检查的100例初产妇、100例经产妇（妊娠次数≥2次）及100例诊断为复发性流产患者为研究对象，收集其孕龄第16~28周的外周血血样，利用固相凝集法检测各组血清中血小板抗体的表达情况。结果：初产妇组、经产妇组及复发性流产组分别检测出血小板血型抗体阳性5、14和26例，卡方分析结果显示妊娠次数及复发性流产发生率与血小板血型抗体阳性率呈显著相关性（P〈0.05）。结论：采用固相凝集法筛查产前血小板血型抗体表达情况可为复发性流产提供诊断和治疗依据。Objective：To investigate the expression of platelet-specific alloantibody in the sera of primipara,pluripara,and recurrent spontaneous abortion （RSA） patients,and analyze the relationship between platelet-specific alloantibody and gravidity or RSA. Methods：A total of 100 primipara, 100 pluripara （gravidity≥2） and 100 RSA patients who received prenatal examination in department of aristogenesis, No. 202 Hospital of PLA from Apr 2015 to Dec 2015 were recruited. The blood samples were collected during 16-28 weeks of pregnancy, and the expression of platelet-specific alloantibody was detected by solid-phase red cell adherence assay. Results：There were 5 positive platelet-specific alloantibody in primipara group, 14 in red all pluripara group,and 26 in RSA group. Platelet-specific alloantibody was significantly associated with gravidity and the incidence of RSA （P〈0.05） by chi-square analysis. Conclusion：Screening the expression of platelet-specific alloantibody during pregnancy can provide evidence for the diagnosis and treatment of RSA.

关 键 词：血小板血型抗体 复发性流产 固相凝集法 产前筛查 

分 类 号：R714.21[医药卫生—妇产科学]