肺炎克雷伯菌生物膜形成机制的研究进展  

Advances in the study of the mechanism of biofilm formation by Klebsiella pneumoniae

作　　者：徐丽[1] 李蓓[1] 

机构地区：[1]湖北医药学院基础医学院,湖北十堰442000

出　　处：《中国病原生物学杂志》2016年第11期1056-1056,I0001-I0003,共4页Journal of Pathogen Biology

基　　金：湖北省教育厅优秀中青年科技创新团队项目(No.T201612)

摘　　要：肺炎克雷伯菌(Klebsiella pneumoniae)是一类可引起呼吸道、泌尿道、伤口等部位感染的条件致病菌。生物膜形成能力已被证实与肺炎克雷伯菌的致病性和耐药性相关。肺炎克雷伯菌生物膜形成受多种调控因子的调控。深入研究肺炎克雷伯菌生物膜形成因素和调控网络,对寻找有效的预防与治疗手段具有重要意义。本文就肺炎克雷伯菌生物膜形成相关因素及其调控机制的最新研究近展进行了综述。Klebsiella pneumoniae is an opportunistic pathogen that frequently causes nosocomial infections,which mainly include respiratory tract infections,urinary tract infections,and wound infections.The ability of Klebsiella pneumoniae for form biofilm has been found to relate to its pathogenicity and drug resistance.The process of biofilm formation is regulated by a variety of regulators.Further study of the factors influencing biofilm formation and networks regulation that formation is important to determining methods of effective prevention and treatment.This review describes recent research on the factors influencing biofilm formation by Klebsiella pneumoniae and the networks regulating that formation.

关 键 词：肺炎克雷伯菌 生物膜 调控机制 综述 

分 类 号：R378[医药卫生—病原生物学]