1%卢立康唑乳膏和1%特比萘芬乳膏治疗足癣的随机单盲对照研究  

Study of 1% luliconazole cream and 1% terbinafine cream in the treatment of tinea pedis:a randomized controlled,single-blind trial

作　　者：高飞[1] 曹萍[1] 

机构地区：[1]云南省第一人民医院皮肤科昆明理工大学附属昆华医院皮肤科,昆明650032

出　　处：《中国真菌学杂志》2016年第5期304-306,共3页Chinese Journal of Mycology

基　　金：中国中西医结合学会皮肤性病专业委员会临床研究基金(CAIM-LLKZ-009)

摘　　要：目的观察和评价1%卢立康唑乳膏治疗足癣的有效性和安全性。方法采用随机、单盲、阳性药物对照研究,将入选患者按照试验设计随机分成2组,实验组外用1%卢立康唑乳膏,每日1次,共2周,对照组外用1%特比萘芬乳膏,每日1次,共2周。开始用药后第2周评价临床和真菌学疗效。结果 86例真菌镜检阳性的患者随机分成2组,每组43例,最后59例患者进入疗效分析。用药2周时,卢立康唑组、特比萘芬组临床有效率分别为96.97%和96.15%(P>0.05),真菌清除率分别为81.82%和80.77%(P>0.05),两组差异无统计学意义。结论 1%卢立康唑乳膏外用治疗足癣安全有效。Objective To observe and evaluate the efficacy and safety of 1%luliconazole cream in the treatment of tinea pedis.Methods In a randomized,single blind,positive drug controlled study,patients selected according to experiment design were randomly divided into 2groups,luliconazole group（1%topical luliconazole cream,1time a day,2weeks）,control group（1%topical terbinafine cream,1time a day,2weeks）.The evaluation of clinical and mycological efficacy was performed after2 weeks.Results Eighty-six cases with fungal positive result were randomly divided into 2groups,43 cases in each group.Finally 59 patients entered effect analysis.Clinical efficiency rates of luliconazole group and terbinafine group were 96.97% and96.15%（P〈0.05）,fungal clearance rates were 81.82% and 80.77%（P〈0.05）.Conclusion It＇s safety and efficacy of treating tinea pedis with luliconazole cream 1%.

关 键 词：卢立康唑 特比萘芬 足癣 临床方案 随机对照试验 

分 类 号：R756.3[医药卫生—皮肤病学与性病学]