早期CPAP辅助呼吸联合盐酸氨溴索治疗新生儿呼吸窘迫综合征的临床疗效  

CPAP Assisted Ventilation Combined with Ambroxol Hydrochloride in the Treatment of Neonatal Respiratory Distress Syndrome

作　　者：孔建亮 刘艳云[1] 

机构地区：[1]江苏省丹阳市第二人民医院儿科,江苏丹阳212300

出　　处：《中外医疗》2016年第32期170-171,174,共3页China & Foreign Medical Treatment

摘　　要：目的探讨新生儿呼吸窘迫综合征采用早期CPAP联合盐酸氨溴索治疗的疗效。方法方便选取于2014年2月—2016年6月期间该院接收的NRDS患者68例,随机分为对照组(常压吸氧联合盐酸氨溴索,n=34)与观察组(早期CPAP即出生后立即给予CPAP呼吸联合盐酸氨溴索治疗,n=34),观察两组患者血气指标及胸部X线评分变化、相关时间指标以及治疗情况比较。结果治疗48 h后,观察组Pa CO2(37.52±4.02)mm Hg明显下降,Pa O2(95.62±6.81)mm Hg、氧合指数(338.6±16.54)mm Hg、p H值(7.39±0.02)明显上升,均与对照组比较差异有统计学意义(P<0.05),且住院时间、CPAP使用时间、用氧时间均低于对照组(P<0.05);观察组治愈率94.2%显著高于对照组(P<0.05),差异有统计学意义。结论新生儿呼吸窘迫综合征采用早期CPAP辅助呼吸联合盐酸氨溴索治疗,疗效显著,可降低并发症发生率,缩短病程,具有推广价值。Objective To investigate the curative effect of neonatal respiratory distress syndrome combined with ambroxol hydrochloride in treating the early CPAP. Methods Convenient 68 cases of NRDS patients during the period from February 2014 to June 2016 in our hospital received, were randomly divided into control group （normal pressure oxygen inhalation combined with ambroxol hydrochloride, n=34） and observation group （early CPAP born CPAP was administered immediately after breathing combined with ambroxol hydrochloride in treating, n=34）, Observe the changes of blood gas index and chest X-ray score, correlation time index and treatment of the two groups. Results After 48h treatment, the observation group Pa- C02 （37.52± 4.02） mmHg decreased significantly, Pa02（95.62 ± 6.81） mmHg, oxygenation inde^（338.6 ± 16.54） mmHg, pH（7.39 ± 0.02） were significantly increased compared with the control group had significant difference（P〈0.05）, and the length of stay in hospital, CPAP use time and oxygen time were lower than that in control group （P〈0.05）; the cure rate of observation group was significantly higher than that in control group （P〈0.05）, the difference was statistically significant. Conclusion Neonatal respiratory distress syndrome by early CPAP assisted breathing combined with ambroxol treatment, obvious curative effect, can reduce the incidence of complications, shorten the course of disease, has the value of popular- ization.

关 键 词：盐酸氨溴索 CPAP 新生儿呼吸窘迫综合征 

分 类 号：R725[医药卫生—儿科]