深圳市儿童医院儿童粪便分离的459株沙门菌分布特征及耐药性  

Distribution characteristics and antimicrobial resistance of 459 strains of Salmonellaisolated from feces of children in Shenzhen Children's Hospital

作　　者：王红梅[1] 王和平[1] 雷旻[1] 周高枫[1] 张交生[1] 彭宝玲[1] 张锐沐 邓继岿[1] 

机构地区：[1]深圳市儿童医院,广东深圳518038

出　　处：《中国感染控制杂志》2016年第11期817-820,共4页Chinese Journal of Infection Control

基　　金：深圳市科技研发资金(JCYJ20160429175723608);深圳市儿童医院重点专科资助项目(szetyy-zdzk-2015-gr)

摘　　要：目的了解儿童粪便分离沙门菌的分布特征及耐药情况。方法分析2012年1月—2015年10月某院患儿粪便标本分离的沙门菌检出情况,以及沙门菌血清型和对常用抗菌药物的敏感性。结果 7 047例患儿送检粪便标本,459例患儿检出沙门菌,总检出率为6.51%。沙门菌肠炎患儿男女比为2.4︰1,其中3岁以下儿童352例(占76.69%);459株沙门菌中5—10月份检出374株(占81.48%),7、8、9月检出数量最多,分别为72、84、78株。沙门菌血清型主要为B群(69.06%)和D群(19.39%),分别以鼠伤寒沙门菌和肠炎沙门菌血清型为主。未检出耐亚胺培南和厄他培南的菌株,沙门菌属对哌拉西林/他唑巴坦、头孢吡肟、头孢他啶、氨曲南和头孢曲松的敏感率均>70%,肠炎沙门菌对头孢类抗生素的敏感率低于鼠伤寒沙门菌,但对复方磺胺甲口恶唑的敏感率高于鼠伤寒沙门菌。结论该院儿童粪便检出的沙门菌主要分离自3岁以下婴幼儿,夏秋季节高发,血清型以鼠伤寒和肠炎沙门菌为主,抗菌药物治疗要结合血清型及药敏结果慎重选择。Objective To understand the distribution characteristics and antimicrobial resistance of Salmonella isolated from feces of children.Methods Salmonella were isolated from fecal specimens of children in a hospital be-tween January 2012 and October 2015,serotypes and susceptibility of Salmonella to commonly used antimicrobial agents were analyzed.Results A total of 7 047 children’s fecal specimens were detected,459 （6.51%）children were isolated Salmonella,the ratio of male to female was 2.4 ∶1,352 （76.69%）children were less than 3 years old;374 strains （81.48%）were isolated from May to October,the numbers of stains isolated in July,August,and September were 72,84,and 78 respectively.Salmonella group B and group D were the most common serotypes,accounting for 69.06%and 19.39% respectively,most were serotypes of Salmonella typhimurium （S.typhimurium）and Salmonella enteritidis （S.enteritidis）.No imipenem-or ertapenem-resistant strains were found,susceptibility of Salmonella to piperacillin/tazobactam,cefepime,ceftazidime,aztreonam,and ceftriaxone were all 〉70%,susceptibility rate of S.enteritidis to cephalosporins was lower than S.typhimurium,but to compound sulfamethoxazole was higher than S.typhimurium. Conclusion Salmonella are mainly isolated from children less than 3 years old in this hospital,summer and autumn are peak seasons,the main serotypes were S.typhimurium and S.enteritidis,antimicrobial therapy should be carefully select-ed in combination with serotypes and antimicrobial susceptibility testing result.

关 键 词：沙门菌 血清型 儿童 粪便 抗药性 微生物 耐药性 流行病学特征 

分 类 号：R378.2[医药卫生—病原生物学]