牛膝各拆分组分的抗炎活性研究  

Anti-inflammatory Effect of Split Fractions of Radix Achyranthis Bidentatae

作　　者：杨柳[1] 颜美玲[1] 吴丽红[1] 姜海[1] 舒尊鹏[1] 杨大宇[1] 杨炳友[1] 王秋红[1] 匡海学[1] 

机构地区：[1]黑龙江中医药大学北药基础与应用研究省部共建教育部重点实验室黑龙江省中药及天然药物药效物质基础研究重点实验室,黑龙江哈尔滨150040

出　　处：《中医药信息》2016年第6期8-11,共4页Information on Traditional Chinese Medicine

基　　金：黑龙江中医药大学优秀创新人才支持计划(2012);黑龙江中医药大学博士创新基金项目(No.2013bs04);黑龙江省博士后基金项目(No.LBH-Z10020);黑龙江省自然科学基金面上项目(No.H201324);高等学校博士学科点专项科研基金新教师类项目(No.20132327120003)

摘　　要：目的:研究牛膝各拆分组分的抗炎活性。方法:建立醋酸所致小鼠腹腔炎症渗出模型和角叉菜胶所致大鼠足趾肿胀模型,考察牛膝各拆分组分的抗炎活性。结果:在醋酸所致小鼠腹腔炎症渗出模型中,牛膝甾酮组分高剂量组和牛膝皂苷组分高、中、低三个剂量组均有不同程度抑制醋酸所致小鼠腹腔毛细血管通透性增加的作用,其中皂苷组分三个剂量组的抑制作用呈剂量依赖性;在角叉菜胶所致大鼠足趾肿胀模型中,牛膝甾酮组分和皂苷组分各剂量在相应时间点上都可以有效降低角叉菜胶所致的大鼠足趾肿胀率,以牛膝甾酮组分高剂量和皂苷组分高、中剂量组的抑制效果最佳。结论:牛膝甾酮组分和皂苷组分都具有一定的抗炎作用,是牛膝药材发挥抗炎作用的药效物质基础。Objective： To research the anti-inflammatory effect of split fractions of Radix Achyranthis Bidentatae. Methods： The models of celiac inflammation effusion mice caused by acetic acid and rats＇ foot swelling caused by carageen glue were established to observe the anti-inflammatory effect of split fractions of Radix Achyranthis Bidentatae. Results： Phytosterones components in high-dose group and tritepene saponins components in three dose groups could inhibit blood capillary permeability of abdominal cavity in the model of celiac inflammation effusion mice caused by acetic acid. In three dose groups the tritepene saponins components showed an anti-inflammatory effect in a dose-dependent manner. Phytosterones components in high-dose group and tritepene saponins components in high and middle dose groups could inhibit the rats＇ foot swelling caused by carageen glue. Conclusion： There is an obviously anti-inflammatory effect of split fractions of Radix Achyranthis Bidentatae.

关 键 词：牛膝 甾酮 皂苷 抗炎 

分 类 号：R285.5[医药卫生—中药学]