聚(1,8-辛二醇-柠檬酸)-co-Pluronic F127生物弹性体的制备与表征  

Preparation and Characterization of Poly(1,8-Octanediol-Citric Acid)-co-Pluronic F127 Bioelastomer

作　　者：王辛[1,2] 吉亚丽[1,2] 

机构地区：[1]东华大学纤维材料改性国家重点实验室,上海201620 [2]东华大学材料科学与工程学院,上海201620

出　　处：《东华大学学报（自然科学版）》2016年第5期641-646,共6页Journal of Donghua University(Natural Science)

基　　金：国家自然科学基金资助项目(51303024)

摘　　要：通过Pluronic F127、柠檬酸和1,8-辛二醇的一步熔融缩聚反应制备得到了可降解的生物弹性体聚(1,8-辛二醇-柠檬酸)-co-F127,并利用傅里叶变换红外光谱(FTIR)、差示扫描量热分析(DSC)、静态水接触角、体外降解、单轴拉伸试验、血小板黏附等分析测试方法对弹性体的结构和性能进行了表征,探讨F127质量分数对弹性体性能的影响.研究结果表明,F127被成功引入到了弹性体网络结构中,它的引入降低了弹性体的玻璃化转变温度,提高了弹性体的亲水性和体外降解速度,而且其水溶胀性表现出一定的温敏特征,同时,弹性体在湿态下的力学性能得到了较大改善,而且血小板黏附和溶血试验也表明弹性体具有更好的血液相容性.The poly（1,8-octanediol-citric）（POC）-co-F127 degradable bioelastomers were prepared by one-step melt polycondensation of Pluronic F127, citric acid and 1, 8-octanediol and characterized by Fourier transform infrared spectroscopy （FTIR）, differential scanning calorimetry （DSC）, static water-contact- angle measurement, in vitro degradation, uniaxial tensile test and platelet adhesion test. The effect of F127 mass fraction on the properties of the elastomer was explored. The result showed that F127 was successfully incorporated into the POC-co-F127 networks, decreasing the glass transition temperature of the elastomer and increasing the hydrophilicity and in vitro degradation rate. Simultaneously, the swelling capacity of POC-co-F127 showed a property of thermo-sensitive, and the mechanical properties under wet condition were improved a lot. Platelet adhesion and hemolysis tests showed that POC-co-F127 exhibited a better blood compatibility.

关 键 词：PLURONIC F127 柠檬酸 1 8-辛二醇 生物弹性体 

分 类 号：O63[理学—高分子化学]