疣迪搽剂加咪喹莫特乳膏联合干扰素局部注射治疗女性尖锐湿疣可行性及稳定性研究  

Study on the feasibility and stability of condyloma wart and imiquimod cream liniment combined with local injection of interferon in treatment of condylo mata acumtnata female

作　　者：黄剑磊[1] 贺晓[1] 刘芳[1] 吴静[1] 刘丹[1] 肖西峰[1] Huang Jianlei He Xiao Liu Fang et al(Department of Obstetrics and Gynecology, Tangdu Hospital, The Fourth Military Medical University （Xi＇an 710038)

机构地区：[1]第四军医大学唐都医院妇产科,西安710038

出　　处：《陕西中医》2016年第10期1275-1277,共3页Shaanxi Journal of Traditional Chinese Medicine

摘　　要：目的：探讨疣迪搽剂加咪喹莫特乳膏联合干扰素局部注射治疗女性尖锐湿疣的临床效果。方法：采用便利抽样法,抽取将120例女性尖锐湿疣患者随机分为试验组（60例）和对照组（60例）。试验组予干扰素皮损内注射,1次/周,同时予疣迪搽剂＋咪喹莫特乳膏涂薄层于疣体,隔日夜间用药1次,至疣体全部消退,疗程均〈16周,每次用药6~10h后清洗患处。对照组仅予CO2激光治疗。结果：试验组痊愈51例、显效5例、好转2例、无效2例,明显优于对照组的41例、7例、3例、9例,差异有统计学意义（P〈0.05）;试验组总复发率为10.0%,对照组总复发率为56.67%,两组差异有统计学意义（P〈0.05）;试验组21例患者在使用干扰素6h内出现轻度低热,均自行消退,10例出现局部红斑,7例出现糜烂,病情不严重。对照组患者术后伤口出现感染6例,10例患者愈后局部遗留瘢痕。结论：疣迪搽剂＋咪喹莫特乳膏联合干扰素局部注射治疗女性尖锐湿疣,其复发率低,安全性高。Objective：To investigate the clinical effect of wart＋ Imiquimod Cream liniment combined with local injection of interferon in the treatment of female genital warts.Methods：By convenience sampling method,extraction of 120 cases of condyloma acuminatum were randomly divided into experimental group（60cases）and control group（60cases）.The trial group were treated with intralesional interferon,1 times/week,at the same time to Imiquimod Cream in thin coated wart liniment＋ wart,day night medication 1 times,until the wart disappeared,lasted less than 16 weeks,each medication 6 ~ 10 hafter cleaning the affected area.The control group only received CO_2 laser treatment. Results：The results of the experimental group 51 cases were cured,5cases markedly effective,2 cases invalid,2 cases improved,significantly better than the control group of 41 cases,7 cases,3 cases,9 cases,the difference was statistically significant（P0.05）;the experimental group total recurrence rate was 10%,control group total relapse rate was 56.67%,there was statistical significant differences between the two groups（P0.05）;experimental group of 21 patients with mild fever appeared in the use of interferon 6h,were self limiting,10 cases of local erythema,erosion occurred in 7 cases,the condition is not serious.The control group patients with postoperative wound infection occurred in 6 cases,10 cases of patients with local scar after healing.Conclusion ：The wart＋ Imiquimod Cream liniment combined with local injection of interferon in the treatment of female genital warts,the recurrence rate is low,high safety.

关 键 词：尖锐湿疣/中西医结合疗法 干扰素 @疣迪搽剂 @咪喹莫特乳膏 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]