补肾中药复方对缺血性损伤大鼠薄型子宫内膜厚度及组织病理学的影响  

Effect of kidney-reinforcing recipe on the thickness and histopathology of thin endometrium caused by Ischemic injury models in experimental rats

作　　者：李楠[1] 陈梅[1] 李翡[1] 孙康[1] Li Nan Chen Mei Li Fei et al(Affiliated Hospital of Shaanxi University Of Chinese Medicine （Xianyang 712000)

机构地区：[1]陕西中医药大学附属医院,咸阳712000

出　　处：《陕西中医》2016年第10期1425-1427,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：陕西省科技厅自然科学基础研究项目(2013JQ4010);陕西省教育厅自然科学科研计划项目(14JK1205)

摘　　要：目的:观察补肾中药复方对缺血性损伤致薄型子宫内膜模型大鼠子宫内膜厚度及组织病理学的影响。方法:SD实验大鼠随机分为4组,分别为空白对照组、模型组、西药组和中药组。除空白对照组以外,其余3组均采用阻断卵巢动脉的方法建立"缺血性损伤"薄型子宫内膜模型,造模成功后空白对照组和模型组给予生理盐水灌胃,西药组给予小剂量阿司匹林灌胃,中药组灌服补肾中药复方,连续灌胃15d后处死。结果:模型组与空白对照组比较,子宫内膜厚度明显萎缩变薄,其差异具有统计学意义;西药组和中药组的内膜厚度与模型组比较均增加,中药组增加的幅度更显著,差异有统计学意义,但与空白对照组比较,无统计学意义。同样,中药组与西药组比较,虽然显示出明显增厚的趋势,但差异无统计学意义。镜下观察模型组子宫内膜层变薄,腺体数量减少,排列疏松,间质致密、细胞变少、变小,血管分布稀疏。西药组和中药组子宫内膜腺体数量较模型组均明显增加,间质血管分布密度集中。而中药组内膜腺体及间质血管发育较西药组成熟度更高。结论:阻断卵巢血供后子宫内膜发生缺血性改变,可以导致内膜厚度变薄。补肾中药复方在增加薄型子宫内膜厚度改善其组织形态中发挥着与小剂量阿司匹林相似且较优的效应。Objective：To observe kidney-reinforcing recipe on the thickness and histopathology of thin endometrium caused by Ischemic injury models in experimental rats.Methods：SD rats werer andomly divided into four groups,respectively blank control group,model group,western medicine group and Chinese medicine group.All groups were established animal model of thin endometrium caused by Ischemic injury,but blank control group.After established model,blank control group and model group were given intragastric administration normal saline.Western medicine group was given low-dosage aspirine.Chinese medicine group was given.Gastric volume was 1ml/100 g.all animals were put to death after 15 days.Results：compared with blank control group,the thickness of endometrium of model group was obvious atrophy thinning.The difference was significant.The endometrial thickness were increased both western medicine group and Chinese medicine group compared with model group,the latter increased more significant.there was no difference with blank control group.Although showed obvious thickening trend in chinese medicine group,but There was no statistically significant difference compared with western medicine group.It was observed that endometrium was thinn ing,gland was fewer,loosely arranged.The stoma was less dense and vascular distribution was sparse in microscope.The number of endometrial glands both western medicine group and Chinese medicine group compared with model group were significantly increased,interstitial vascular distribution was density and Chinese traditional medicine group of endometrial glands and stroma vascular development maturity was higher than western medicine group.Conclusion Endometrial Ischemic injury caused by temporary interrupting the ovary artery blood supply will lead to endometrial thickness thinning.Kidney-reinforcing recipe can increase the thickness and form of thin endometrium and play a similar to low-dose aspirin and a better effect.

关 键 词：补肾中药复方 薄型子宫内膜 子宫内膜厚度 组织病理学 

分 类 号：R96[医药卫生—药理学]