中药与矿物盐微粉对急性血瘀模型大鼠血液流变性的影响  

Effect of traditional Chinese medicine and mineral salts micropowder on hemorheology in rats of acute blood stasis model

作　　者：傅卫红[1] 张青[1] 周玉宝[1] 张琳静[1] 彭立静[1] 王永兴[1] 李超民[1] Fu Weihong Zhang Qing Zhou Yubao et al(The 451st Hospital of PLAXi＇an 710032)

机构地区：[1]解放军第四五一医院,西安710054

出　　处：《陕西中医》2016年第10期1433-1435,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：全军保健专项课题(12BJ207)

摘　　要：目的:探讨中药与矿物盐微粉对急性血瘀模型大鼠血液流变学指标的影响。方法:采用冰水浴和皮下注射盐酸肾上腺素致大鼠急性血瘀模型,检测全血低切、中切及高切黏度、血浆黏度、红细胞压积和纤维蛋白指数等指标,探讨中药与矿物盐微粉对急性血瘀模型大鼠血液流变学指标的影响。结果:血瘀模型组高、中、低切变率的全血黏度、血浆黏度、红细胞压积、纤维蛋白较正常对照组明显升高(P<0.01)。中药与矿物盐微粉各剂量组的全血黏度均有不同程度的下降,其中大剂量组与模型组比较有显著性差异(P<0.05),中、小剂量组较模型组降低,但无统计学意义;中药与矿物盐微粉大、中剂量组的血浆黏度较模型组有显著性降低(P<0.05);各剂量组的红细胞压积、纤维蛋白与模型组相比有不同程度的降低,但无统计学差异。结论:中药与矿物盐微粉能够改善急性血瘀模型大鼠的全血和血浆黏度,具有明显的活血化瘀作用。Objective：To explore the effects of external application of the Traditional Chinese medicine and mineral salts（TCM-MS）micropowder on hemorheology in acute blood stasis model of rats.Methods：Sixty SD rats were randomly divided into the normal group,the model group,the Di＇ao xinxuekang capsules control group,and high dose（150g·kg-1）,middle dose（45g·kg-1）and low dose（15g·kg-1）of TCM-MS micropowder group,with 10 rats in each group.The TCM-MS micropowder groups were administered with external application of TCM-MS micropowder twice per day for 7dseparately,where as the normal and model group were orally administered with distilled water,and the control group were orally administered with the Di＇ao xinxuekang capsules.The models of acute blood stasis were established by means of subcutaneous injection of adrenaline and ice water bath after treatment for 6days.The hemorheology indexes were measured 7dafter continuous administration in order to investigate the influences of TCM-MS micropowder on the acute blood stasis rat model.Results：The whole blood low shear viscosity,medium shear viscosity,high shear viscosity and plasma viscosity,hematocrit（HCT）and plasma fibrinogen（FIB）of model control group were significantly increased compared with those of the normal group（P0.01）;The whole blood viscosity were decreased in different doses of TCM-MS micropowder group,and compared with the model group,there was significant decrease in the high dose group of TCM-MS micropowder（P0.05）.The plasma viscosity index were significantly reduced in high and middle dose of TCM-MS micropowder group（P0.05）.There were no significant difference in hematocrit（HCT）and plasma fibrinogen（FIB）between the TCM-MS micropowder group and the model group.Conclusion：The TCM-MS micropowder could significantly improve abnormal change of hemorheology on actue blood stasis model of rats.

关 键 词：血瘀症 血液流变学 微循环障碍 动物 实验 大鼠 

分 类 号：R96[医药卫生—药理学]