成人肾病综合征患者高尿酸血症的发病率及相关因素分析  

Hyperuricemia Risk in Adult Patients with Primary Nephrotic Syndrome and Its Correlated Factors

作　　者：杨再波[1] 齐卡[1] 李建军[1] 张志浩[1] 马路[1] 

机构地区：[1]北京军区北戴河疗养院全军肾病中西医结合治疗中心,秦皇岛北戴河066100

出　　处：《标记免疫分析与临床》2016年第11期1260-1263,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨成人原发性肾病综合征(primary nephrotic syndrome,PNS)患者高尿酸血症(hyperuricemia,HUA)的发病率及其相关影响因素。方法回顾性分析2010年1月至2012年3月在我院首次诊断为PNS的成人患者共306例,分别测定其血尿酸(serum uric acid,SUA)、白蛋白(albumin,ALB)、血清肌酐(serum creatinine,Scr)、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、同型半胱氨酸(homocysteine,Hcy)等指标,以328例"健康"体检者作为对照组,进行HUA发病率调查及相关因素分析。结果 PNS组的平均SUA水平及HUA的发病率明显高于对照组(P均<0.001);PNS组中,男性平均SUA水平及HUA发病率明显高于女性(P<0.001;P=0.008);各病理类型中,以局灶节段性肾小球硬化症的HUA发病率最高,但与其它病理类型间的差异无统计学意义(P>0.05)。PNS组SUA水平与TG、Scr、Hcy呈显著正相关关系(P=0.022;P<0.001;P<0.001),而与ALB、TC无显著相关性(P=0.422;P=0.325)。结论成人PNS患者HUA的发病率明显高于正常人群,SUA水平与TG、Scr、Hcy水平相关。Objective To evaluate the morbidity and associated factors of hyperuricemia in adult patients with primary nephrotic syndrome（ PNS）. Methods A total of 306 patients with PNS in our department from January 2010 to March 2012 were studied,and 328 healthy individuals as a control group. All subjects were examined with serum uric acid（ SUA）,albumin（ ALB）,serum creatinine（ Scr）,triglycerides（ TG）,total cholesterol（ TC）,and homocysteine（ Hcy）,. Incidence and related factors of hyperuricemia in these two groups were analyzed. Results SUA level and the incidence of hyperuricemia in PNS group were all significantly elevated when compared with the control group（ P〈 0. 001 and P〈 0. 001,respectively）. SUA level and hyperuricemia risk in male patients was much higher than in female patients（ P〈 0. 001 and P =0. 008,respectively）. In various pathological types,the focal segmental glomerulosclerosis has the highest incidence with HUA,but the difference between with other pathological types had no statistical difference（ P〉 0. 05）. SUA level in PNS group was positively correlated with TG,Scr,and Hcy（ P = 0. 022,P 0. 001 and P〈 0. 001,respectively）,but not with ALB and TC（ P = 0. 422 and P = 0. 325,respectively）.Conclusion The incidence of hyperuricemia in adult patients with primary nephrotic syndrome are significantly higher than healthy individuals,and SUA level in these patients is correlated with TG,Scr,and Hcy levels.

关 键 词：原发性肾病综合征 高尿酸血症 甘油三酯 血清肌酐 同型半胱氨酸 

分 类 号：R692[医药卫生—泌尿科学]