左旋布比卡因浓度和容量选择对小儿骶管阻滞效果影响  

Effect of Different Concentrations and Volumes of Levobupivacaine on Caudal Block in Children

作　　者：屈美敏[1] 周力[1] 陈珏[1] 张锡凤[1] 

机构地区：[1]南京医科大学附属南京儿童医院麻醉科,南京210008

出　　处：《基因组学与应用生物学》2016年第11期2956-2960,共5页Genomics and Applied Biology

摘　　要：为探究不同浓度和容量左旋布比卡因对小儿骶管阻滞效果的影响,研究人员对我院2013年至2015年收治的90例小儿手术患者病例进行了研究。所有患儿采用左旋布比卡因行骶管阻滞麻醉,按照随机数表法平均分至A^F 6组,分别给予不同浓度和容量的左旋布比卡因:A组(0.25%,1.0 m L/kg)、B组(0.25%,0.7 m L/kg)、C组(0.20%,1.0 m L/kg)、D组(0.20%,0.7 m L/kg)、E组(0.15%,1.0 m L/kg)、F组(0.15%,0.7 m L/kg)。平均动脉压,A组明显低于C组和E组,B组显著低于D组和F组。E组麻醉时间、下肢肌力恢复时间及肛门排气时间明显低于A、C两组,而补充氯胺酮次数及疼痛评分显著高于A、C两组。F组麻醉时间、下肢肌力恢复时间及肛门排气时间明显低于B、D两组,而补充氯胺酮次数及疼痛评分显著高于B、D两组。E、F两组不良反应发生率显著高于其余4组。C组疼痛评分显著低于D组。0.20%的左旋布比卡因1.0 m L/kg用于小儿骶管阻滞既可达到满意麻醉效果,且并发症少,可作为最佳有效浓度。To explore the effect of different concentrations and volumes of levobupivacaine on caudal block in children, 90 cases children patients treated with surgeries in our hospital from Jan. 2013 to Jan. 2015 were selected. They were divided into 6 groups （A-F） randomly. They were given different concentrations and volumes of levobupivacaine for caudal block： group A （0.25%, 1.0 mL/kg）, group B （0.25%, 0.7 mL/kg）, group C （0.20%, 1.0 mL/kg）, group D （0.20%, 0.7 mL/kg）, group E （0.15%, 1.0 mL/kg）, group F （0.15%, 0.7 mL/kg）. Anesthesia related indicators were compared among 6 groups. MAP of group A was lower than that of group C and E （/9〈0.05）; MAP of group B was lower than that of group D and F （p 〈0.05）. The anesthesia time, recovery time of lower limb muscle strength and anal exhaust time of group E and F were lower than those of other 4 groups, and the ketamine supplementation, pain level and incidence of adverse reactions were higher than those of other 4 groups （p 〈0.05）. 0.20% levobupivacaine for 1.0 mL/kg is optimal effective concentration on caudal block in children.

关 键 词：骶管阻滞 左旋布比卡因 小儿 浓度 容量 

分 类 号：R726.1[医药卫生—儿科]