雌激素在软骨中作用机制研究进展  

Protective effects of estrogen on cartilage: current literatare review

作　　者：李健[1] 姚玉龙[1] 张磊磊[1] 程细高[1] 

机构地区：[1]南昌大学第二附属医院骨科,江西南昌330006

出　　处：《中国矫形外科杂志》2016年第23期2156-2159,共4页Orthopedic Journal of China

基　　金：国家自然科学基金项目(编号:81060147);江西省教育厅科学研究项目(编号:03424013)

摘　　要：广泛查阅近年国内外有关雌激素对软骨干预效果及作用机制的相关文献,并进行综合分析。雌激素可促进软骨细胞增殖,影响软骨细胞各种炎性细胞因子的分泌,并且可调节影响软骨形成的关键蛋白的表达,因此雌激素对软骨具有潜在的保护作用。雌激素的软骨保护作用有望成为一种软骨退行性疾病的调修药,但目前相关研究尚不完善,需要进一步完善基础及临床研究,阐明雌激素在软骨中的作用机制,明确雌激素用于预防和治疗软骨退行性疾病的风险和收益。The relevant literature about the effects and mechanism of estrogen intervening cartilage in recent years was ex- tensively reviewed and comprehensively analyzed. Estrogen could promote the proliferation of chondrocyte in articular cartilage, and it could affect the secretion of inflammatory cytokines on cartilage cells, at the same time, adjust the expression of key pro- tein which affect cartilage formation. Therefore it has a potential protective effect on cartilage during the progression of cartilage degenerative disease. However, further studies are needed to clarify the mechanism of estrogen in cartilage degenerative disease and finally confirm the risks and benefits of estrogen in the treatment of cartilage degenerative diseases.

关 键 词：软骨 雌激素 雌激素受体 

分 类 号：R68[医药卫生—骨科学]