米诺环素治疗儿童耐药肺炎支原体肺炎临床疗效观察  

Minocycline in Children with Macrolide-Resistant Mycoplasma Pneumoniae Pneumonia

作　　者：韩旭[1] 苗耐英[1] 温慧敏[1] 王彩虹[1] 

机构地区：[1]中国石油天然气集团公司中心医院,河北廊坊065000

出　　处：《儿科药学杂志》2016年第12期17-19,共3页Journal of Pediatric Pharmacy

基　　金：廊坊市科学技术研究与发展计划项目;编号20120130026

摘　　要：目的:观察米诺环素治疗儿童耐药肺炎支原体肺炎的临床疗效,探讨儿童耐药肺炎支原体肺炎的有效治疗方法。方法:观察2012年3月至2015年12月中国石油天然气集团公司中心医院儿科病房诊断为耐药肺炎支原体肺炎、经阿奇霉素治疗2 d发热不退的患儿59例,随机分为治疗组29例和观察组30例,治疗组患儿在阿奇霉素治疗的基础上加用米诺环素治疗,对照组患儿继续应用阿奇霉素治疗,比较两组患儿抗生素治疗后发热时间、总热程、住院时间、并发症发生率。结果:治疗组患儿治疗后发热时间、总热程、住院时间分别为(3.71±1.01)d、(6.45±1.34)d、(8.34±2.17)d,均短于对照组的(5.22±1.21)d、(8.28±1.17)d、(11.28±2.83)d,差异有统计学意义(P均<0.05)。治疗组2例出现并发症,对照组3例出现并发症,两组比较差异无统计学意义(P>0.05)。结论:米诺环素治疗儿童耐药肺炎支原体感染有效,值得临床推广应用。Objective： To investigate the clinical efficacy of minocycline in children with macrolide-resistant Mycoplasma pneumoniae pneumonia.Methods： Fifty-nine children who were diagnosed as macrolide-resistant Mycoplasma pneumoniae pneumonia and fever persisted for two days after azithromycin treatment from March 2012 to December 2015 were divided randomly into two groups.The treatment group（29 cases） was given minocycline treatment and azithromycin treatment while the control group（30 cases） was only given azithremycin treatment.The differences between the two groups in febrile days after administration of antibiotic treatment,total febrile days,length of stay and the occurrences of complications were compared.Results： In treatment group,febrile days after administration of antibiotic treatment was（3.71±1.01） d,total febrile days was（6.45±1.34） d and length of stay was（8.34±2.17） d,in control group,febrile days after administration of antibiotic treatment was（5.22±1.21） d,total febrile days was（8.28±1.17） d and length of stay was（11.28±2.83） d,the differences were significant in two groups（P〈0.05）.There was no significant difference in the occurrence of complications between the two groups（P 〉 0.05）.Conclusion： Minocycline is effective in treatment in children with macrolide-resistant Mycoplasma pneumoniae pneumonia.

关 键 词：肺炎支原体 耐药 分子药敏试验 米诺环素 

分 类 号：R725.1[医药卫生—儿科]