血清脂蛋白相关磷脂酶A2、同型半胱氨酸、高密度脂蛋白胆固醇与冠状动脉病变相关的临床研究  

Research on the relationships of serum lipoprotein-associated phospholipase A2,homocysteine,high density lipoprotein cholesterol levels with coronary artery lesion

作　　者：张卫群[1] 王东霞[1] 张菁菁[1] 王伟[1] ZHANG Wei-qun WANG Dong-xia ZHANG Jing-jing WANG Wei(The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453003, Chin)

机构地区：[1]新乡医学院第三附属医院,河南新乡453003

出　　处：《中国卫生检验杂志》2016年第22期3269-3271,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨脂蛋白相关磷脂酶A2(Lp-PLA2)、同型半胱氨酸(Hcy)、高密度脂蛋白胆固醇(HDL-C)与冠状动脉病变的相关性。方法选取本院2015年1月-2016年1月收治的胸痛患者中86例作为研究对象,并根据其冠状动脉有无病变分为病变组(43例)和对照组(43例),比较2组患者血清中Lp-PLA2、Hcy、HDL-C、hs-CRP、PLT、D-二聚体水平差异。结果研究组Lp-PLA2、Hcy水平高于对照组,而HDL-C水平低于对照组,差异均有统计学意义(P<0.05)。但2组间hs-CRP、PLT、D-二聚体水平差异均无统计学意义(P>0.05)。结论 Lp-PLA2、Hcy、HDLC与冠状动脉病变密切相关,而hs-CRP、PLT、D-二聚体与冠状动脉病变无关。Objective To investigate the relationships of serum lipoprotein- associated phospholipase A2（ Lp- PLA2）,homocysteine（ Hcy）,high density lipoprotein cholesterol（ HDL- C） with coronary artery lesion. Methods 86 patients with chest pain were collected from our hospital during Jan. 2015- Jan. 2016 and divided into the lesion group（ n = 43） and the control group（ n = 43） according to whether there was coronary artery lesion. The levels of Lp- PLA2,Hcy,HDL- C were compared between the two groups. Results The levels of Lp- PLA2 and Hcy were higher in the lesion group than those of the control group,with difference statistically significant（ P〈0. 05）. While the difference on levels of hs- CRP,PLT and D- D were not statistically significant between two groups（ P〈0. 05）. Conclusion The levels of Lp- PLA2,Hcy,HDL- C are closely associated with coronary artery lesion,while hs- CRP,PLT,D- D have nothing to do with coronary artery lesions.

关 键 词：脂蛋白相关磷脂酶A2 同型半胱氨酸 高密度脂蛋白胆固醇 冠状动脉病变 

分 类 号：R541.4[医药卫生—心血管疾病]