银杏叶提取物注射液药效再评价研究  

Efficacy re-evaluation of extract from Ginkgo Biloba leaves injection

作　　者：谭莉萍[1,2] 廖弈秋[1] 刘宏[1] 李泮霖[1] 黄昕[1] 吴忠[1] 彭维[1] 苏薇薇[1] TAN Li-ping LIAO Yi-qiu LIU Hong LI Pan-lin HUANG Xin WU Zhong PENG Wei SU Wei- wei(School of Life Sciences, Sun Yat-sen University, Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Tropical and Subtropical Plant Resources, Guangzhou 510275 Medical College of Shaoguan Oniversity, Shaoguan Guangdong 512026)

机构地区：[1]中山大学生命科学学院广东省中药上市后质量与药效再评价工程技术研究中心广东省热带亚热带植物资源重点实验室,广州510275 [2]韶关学院医学院,广东韶关512026

出　　处：《中南药学》2016年第11期1159-1162,共4页Central South Pharmacy

基　　金：国家科技支撑计划项目(No.2012BAI29B09);广东省中医药局科研项目(No.20161050)

摘　　要：目的开展银杏叶提取物注射液药效再评价研究。方法建立大鼠急性血瘀模型,观察血液流变学及凝血功能等指标;采用双光子活体成像技术,对小鼠脑血管闭塞-溶栓过程进行实时监测。结果银杏叶提取物注射液在血液流变性、凝血功能、血管内皮功能、炎症应答及氧化应激等方面具有调控作用;能够促进脑部微血管栓塞部位的血液流动,加快栓块溶解。结论银杏叶提取物注射液可有效防治脑部和周围血流循环障碍。Objective To re-evaluate the efficacy of extract from Ginkgo Biloba leaves injection（EGBLI）. Methods An acute blood stasis rat model was used to evaluate the protective effects of EGBLI. The two-photon laser-scanning microscopy technique was set up to assess the improvements of EGBLI on the cerebral thrombolysis in mice. Results EGBLI had positive effects on the haemorheology, blood coagulation, oxidative stress, inflammatory response, and vascular endothelial function. Moreover, EGBLI promoted the recovery of injured cerebral arterioles to some degree. Conclusion EGBLI has protective effects on the cerebral and peripheral blood circulation disorders. This study provides useful guidance for the clinical use of EGBLI.

关 键 词：中药注射剂 银杏叶提取物注射液 药效再评价 

分 类 号：R473.3[医药卫生—护理学]