阻塞型睡眠呼吸暂停综合征与肺高血压研究进展  

Research Progress of Obstructive Sleep Apnea Syndrome and Pulmonary Hypertension

作　　者：董学峰 曾奕明[2] 

机构地区：[1]泉州医学高等专科学校,福建泉州362100 [2]福建医科大学附属二院,福建泉州362000

出　　处：《哈尔滨医药》2016年第5期589-591,共3页Harbin Medical Journal

摘　　要：阻塞型睡眠呼吸暂停综合征是由于患者在睡眠时上呼吸道的阻塞从而导致机体长期反复的间断性缺氧,可引起肺高血压,最终可发展成肺心病。其发生机制可能是由于肺动脉平滑肌细胞钙、钾通道功能失常,血管内皮功能紊乱、免疫炎症反应、凝血功能障碍、肺血管的重塑等因素相互作用的结果。In patients with obstructive sleep apnea syndrome is due to the sleep of the upper respiratory tract obstruction resulting in the body of intermittent hypoxia repeatedly for a long time, can cause pulmonary hypertension, may eventually develop into cor pulmonale.The mechanism may be due to pulmonary artery smooth muscle cell calcium,potassium channel function disorder,vascular endothelial dysfunction,immune inflammation,blood clotting disorders,pulmonary vascular remodeling factors such as the result of the interaction.

关 键 词：阻塞型睡眠呼吸暂停综合征 慢性间断性缺氧 肺高血压 

分 类 号：R56[医药卫生—呼吸系统]