PLR、NLR、APRI指数、FIB-4指数对丙肝病毒清除的预测意义  

PLR, NLR, APRI, FIB4 index to predict the significance of hepatitis C virus clearance

作　　者：陈会枝[1] 

机构地区：[1]郑州大学第一附属医院检验科,450052

出　　处：《中国实用医刊》2016年第21期37-39,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨血小板、淋巴细胞比值（PLR）、中性粒细胞、淋巴细胞比值（NLR）、天门冬氨酸氨基转移酶和血小板比值（APRI指数）和FIB-4指数对丙肝病毒清除的预测意义。方法对比分析93例慢性丙型肝炎患者和40名健康体检者的数据，通过计算得到PLR、NLR、APRI、FIB-4。同时进一步分组对比分析不同丙肝患者的各指标。结果与健康对照组比较，慢性丙肝患者APRI、FIB-4升高，NLR降低，两组差异未见统计学意义。进一步分组分析，病毒清除患者PLR明显高于未治疗和治疗后病毒未清除患者。结论PLR、NLR、APRI、FIB-4均与丙肝病毒清除存在一定关联，合理运用可帮助临床更好的诊断和治疗。Objective To explore the values of platelet-to-lymphocyte ratio （PLR）, neutrophil- to-lymphocyte ratio （ NLR）, aspartate aminotransferase-to-platelet ratio index （APRI） and FIB-4 index in prediction of virus removel in patients with chronic hepatitis C. Methods Ninety-three CHC patients and 40 cases healthy controls were included. The PLR, NLR, APRI and FIB-4 of all the patients were calculated by corresponding formula. Results Compared with healthy controls , CHC patients had sig- nificant higher APRI and FIB-4 levels and lower NLR level, while PLR increased but there was not sig- nificantly statistically difference between the two groups. Further subgroup analysis, viral clearance in pa- tients with PLR was significantly higher than in untreated and treated patients without viral clearance. Conclusions PLR, NLR, APRI and FIB-4 all correlate with virus removal in chronic hepatitis C, rational use can help clinical diagnosis and treatment.

关 键 词：血小板淋巴细胞比值 中性粒细胞淋巴细胞比值 血小板指数 FIB-4指数 慢性丙型肝炎 病毒清除 

分 类 号：R512.63[医药卫生—内科学] R446.6[医药卫生—临床医学]