慢性鼻-鼻窦炎骨炎严重程度影响因素分析  

Analysis of the correlation factors of osteitis in patients with chronic rhinosinusitis

作　　者：谢存存[1,2] 田鹏[1] 刘翔[1] 邹华[1] 林泓霖[1] 潘忠[1] 祝麟[1] 

机构地区：[1]中山大学孙逸仙纪念医院耳鼻咽喉头颈外科,广东广州510120 [2]郑州大学河南省人民医院耳鼻咽喉科,河南郑州450000

出　　处：《中国耳鼻咽喉头颈外科》2016年第11期619-622,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：广东省自然科学基金自由申请项目(2014A030313158)

摘　　要：目的探讨慢性鼻-鼻窦炎(CRS)骨炎严重程度的影响因素。方法收集CRS患者82例,男59例,女23例。采用整体骨炎评分系统(global osteitis scoring scale,GOSS)评价骨炎严重程度,并用Lund-Mackay评分及Lund-Kennedy评分来客观评价患者CRS的严重程度,检测外周血嗜酸性粒细胞数和嗜酸性粒细胞百分比,并收集外周血Th17细胞含量、血清总Ig E、特异性Ig E含量及C反应蛋白含量。GOSS与Lund-Mackay评分及Lund-Kennedy评分、血嗜酸性粒细胞含量及百分比、外周血Th17细胞百分比、血清总Ig E及特异性Ig E含量及C反应蛋白含量之间的相关性,采用SPSS13.0软件包进行统计学分析。结果骨炎GOSS评分与Lund-Mackay评分之间呈显著正相关性(r=0.823,P<0.01);骨炎GOSS评分与Lund-Kennedy存在高度正相关性(r=0.683,P<0.01);骨炎GOSS评分与血中的总Ig E呈正相关性(r=0.3,P<0.1),但有骨炎组与无骨炎组患者外周血特异性Ig E含量无明显差别;骨炎GOSS评分与血Th17细胞百分比、血嗜酸性粒细胞含量及C-反应蛋白含量均无相关性。结论 CRS骨炎严重程度与血中总Ig E密切相关,与患者鼻窦黏膜炎症严重程度相关。OBJECTIVE To analyze the correlation factors of the severity of osteitis in patients with chronic rhinosinusitis.METHODS 82 patients with chronic rhinosinusitis with or without nasal polyps were studied.CT scan of the sinus was analyzed by PHILIPS MxLite View software,using GOSS to grade the severity of the osteitis.The objective severity of chronic rhinosinusitis was scored using Lund-Mackay and Lund-kennedy.The blood of the82 patients were collected and the number and percentage of eosinophil,the percentage of Th17 cells were tested with flow cytometry.The total serum IgE level and the specific serum IgE level,C-reactive protein were also measured.Then the correlation of the factors with the severity of the osteitis were analyzed.RESULTS There was a remarkable association between GOSS and Lund-Mackay scores（r=0.823,P〈0.01）.There was an association between GOSS and Lund-kennedy scores（r=0.683,P〈0.01）.There was a positive association between GOSS and the total serum IgE level（r=0.3,P〈0.1）,but there was no difference of special IgE level between osteitis patients and nonosteitis patients.There was no association between GOSS scores and the percentage of Thl7 cells,the number and percentage of eosinophil and the C-Reactive Protein.CONCLUSION The severity of chronic sinusitis was associated with the total serum IgE level.The severity of patients＇ mucosal inflammation can influence the severity of osteitis.

关 键 词：鼻窦炎 骨炎 免疫球蛋白E 

分 类 号：R765[医药卫生—耳鼻咽喉科]