荆芥连翘汤加减对溃疡性结肠炎患者血清TNF-α、IL-2的调节作用  

Regulating Effect of Modified Jingjie Lianqiao Decoction on Serum TNF-α and IL-2 in Patients with Ulcerative Colitis

作　　者：张艳君 

机构地区：[1]河北省唐山市中医医院脾胃病科,河北唐山063000

出　　处：《山东中医杂志》2016年第11期966-968,共3页Shandong Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(编号:2014262)

摘　　要：目的 :观察荆芥连翘汤加减对溃疡性结肠炎(UC)患者血清TNF-α及IL-2含量的影响及作用机制。方法:将UC大肠湿热兼肺热证患者60例随机分为两组,治疗组32例口服荆芥连翘汤加减及美沙拉嗪肠溶片,西药对照组28例口服美沙拉嗪肠溶片,3个月后对比两组血清TNF-α、IL-2含量的变化。结果:荆芥连翘汤加减能使UC患者血清TNF-α含量明显降低、IL-2含量明显升高,其调节作用与对照组比较差异具有统计学意义(P<0.05)。结论:荆芥连翘汤加减能明显调节溃疡性结肠炎TNF-α及IL-2水平,并使其趋向正常,发挥减轻炎症、调节免疫的功效。Objective：To observe the regulating effect of modified Jingjie Lianqiao decoction on serum TNF-αand IL-2 in patients with ulcerative colitis（UC）,and to explore the mechanisms. Methods：Total 60 cases patients with UC of large intestine damp-heat with lung heat type were randomly divided into treatment group and western medicine group. In the treatment group there were 32 patients given oral administration of modified Jingjie Lianqiao decoction and enteric-coated mesalarnine tablet,in the western medicine group there were 28 patients given oral administration of enteric-coated mesalarnine tablet. After 3 months,changes of serum TNF-α and IL-2 levels in two groups were compared. Results：Modified Jingjie Lianqiao decoction could decrease serum TNF-α level significantly,while increase serum IL-2 level significantly,with statistical significance（P〈0.05）,compared with the western medicine group. Conclusion：Modified Jingjie Lianqiao decoction could regulate TNF-α and IL-2 levels to be normal,therefore to reduce inflammation and regulate the immunity.

关 键 词：溃疡性结肠炎 荆芥连翘汤加减 TNF-Α IL-2 

分 类 号：R259.741[医药卫生—中西医结合]