心房颤动患者外周血中性粒细胞淋巴细胞比值测定及其临床意义  

Detection of peripheral blood neutrophil to lymphocyte ratio in patients with atrial fibrillation and its clinical significance

作　　者：汪郡 田建伟[1] 余成[1] 张娜[1] 徐斌[1] 吴超[1] 廖明媛 

机构地区：[1]解放军空军总医院心内科,北京100036

出　　处：《中国实用医刊》2016年第22期1-4,共4页Chinese Journal of Practical Medicine

摘　　要：目的：观察炎症指标外周血中性粒细胞淋巴细胞比值（NLR）在心房颤动患者中的水平变化，探讨NLR 与房颤的关系及其临床意义。方法连续选取2013年1月至2015年12月房颤患者150例，其中阵发性房颤68例（阵发性房颤组），持续性房颤82例（持续性房颤组），对照组为同期住院的无房颤病史的窦性心律患者69例。收集临床资料，比较各组临床特征、超声心动图指标和外周血 NLR 的差异，分析导致房颤发生的影响因素。结果各组年龄、高血压病史和冠心病病史比较差异均有统计学意义（P〈0.05）。阵发性房颤组左心室收缩末期左房前后径（LAD）较对照组升高[41.00（38.00~43.00）比38.00（36.00~40.00），P〈0.05]；持续性房颤组 LAD （48.56±6.85）较阵发性房颤组升高（ P〈0.01）。阵发性房颤组左室射血分数（ LVEF）较对照组降低[0.57（0.54~0.59）比0.58（0.57~0.59），P〈0.01）]；持续性房颤组 LVEF 较阵发性房颤组降低[0.55（0.52~0.57）， P〈0.01]。阵发性房颤组 NLR 较对照组升高（2.13±0.78比1.75±0.65，P〈0.01）；持续性房颤组 NLR 较阵发性房颤组升高[2.66（1.84~3.63），P〈0.01]。多因素 Logistic 回归分析显示 NLR 是房颤的独立危险因素（比值比：2.349，95%可信区间：1.415~3.901，P =0.001）。结论房颤患者外周血 NLR 增高，NLR 是房颤的独立危险因素。Objective To observe the change of inflammatory biomarkers peripheral blood neu-trophil to lymphocyte ratio level,and thus to investigate the relationship between neutrophil to lymphocyte ratio and atrial fibrillation,and the clinical significance of neutrophil to lymphocyte ratio for atrial fibrilla-tion. Methods A total of 150 patients with atrial fibrillation hospitalizd from January 2013 to December 2015 were selected,including 68 patients with paroxysmal atrial fibrillation（ patients with paroxysmal atrial fibrillation group）and 82 patients with persistent atrial fibrillation（ persistent atrial fibrillation goup）;at the same time,69 patients with sinus rhythm without history of atrial fibrillation hospitalized were selected as the control group. The clinical data were collected,the differences of clinical features, echocardiographic indexes and peripheral blood neutrophil to lymphocyte ratio among the three groups were compared, and the factors influencing the occurrence of atrial fibrillation were analyzed. Results There was significant difference among the three groups in age,history of hypertension,history of coronary heart disease（P〈 0. 05）. left atrial diameter of Paroxysmal atrial fibrillation group[41. 00 （38. 00 - 43. 00）]was higher than that of the control group[38. 00（36. 00 - 40. 00）,P〈 0. 05];the left atrial diameter of persistent atrial fibrillation group（48. 56 ± 6. 85）was higher than that of the parox-ysmal atrial fibrillation group（P〈 0. 01）. The left ventricular ejection fraction of paroxysmal atrial fibril-lation group[0. 57（0. 54 - 0. 59）]was lower than that of the control group[0. 58（0. 57 - 0. 59）,P〈0. 01];the left ventricular ejection fraction of persistent atrial fibrillation group[0. 55（0. 52 - 0. 57）] was lower than that the paroxysmal atrial fibrillation group（P〈 0. 01）. Neutrophil to lymphocyte ratio in＆amp;nbsp;paroxysmal atrial fibrillation group（2. 13 ± 0. 78）increased,compared with the control group（1. 75 ± 0. 65,

关 键 词：心房颤动 中性粒细胞淋巴细胞比值 炎症 独立危险因素 

分 类 号：R541.75[医药卫生—心血管疾病]