血管化鹿茸软骨组织与骨组织修复  

Vascularized antler cartilage and bone tissue repair

作　　者：付晶[1] 褚文辉[2] 孙红梅[2] 李春义[2] 马丽娟[3] 

机构地区：[1]吉林农业大学中药材学院,吉林省长春市130000 [2]中国农业科学院特产研究所,吉林省长春市130000 [3]吉林农业科技学院,吉林省吉林市132000

出　　处：《中国组织工程研究》2016年第46期6970-6977,共8页Chinese Journal of Tissue Engineering Research

基　　金：吉林省自然科学基金(20140101139JC)~~

摘　　要：背景:鹿茸是惟一可以周期性再生的哺乳动物类器官,其软骨组织内富含血管。研究鹿茸血管化的软骨,对于揭开鹿茸独特的生物学特性以及对骨组织修复和再生医学有重要的意义。目的:综述鹿茸软骨组织中血管的分布、鹿茸中血管的发生过程及机制探索、影响鹿茸血管生成的细胞因子,分析鹿茸模型对于骨组织工程的独特优势,为组织工程中骨组织的修复提供医学参考。方法:检索PubM ed与CNKI数据库。在PubM ed中的检索词为deer antler,Bone tissue engineering,vascularized cartilage;在CNKI数据库中的检索词为鹿茸,骨组织工程,鹿茸血管化软骨。纳入涉及鹿茸组织学与形态学、鹿茸软骨、血管化软骨以及骨组织工程研究的相关文章,排除与内容无关和重复文章。结果与结论:(1)通过初检与筛选共纳入51篇文献;(2)鹿茸是一种可以周期性再生的软骨/骨组织,与关节软骨不同鹿茸的软骨组织内含有丰富的血管,且生长速度极快可达2.7 cm/d;(3)目前国内外学者已经对鹿茸软骨组织的血管化进行了初步研究,并取得了一定的研究成果。通过探讨鹿茸软骨组织中血管的分布,鹿茸中血管的发生过程与机制,以及影响鹿茸血管生成的细胞因子,分析鹿茸模型对于骨组织工程的独特优势,对利用鹿茸软骨组织血管化机制在临床上进行工程软骨血管化提供参考。BACKGROUND： Deer antlers are the only known mammalian organ that can regenerate periodically, and its cartilage is rich in blood vessels. Study on deer antler vascularized cartilage can uncover the antler biological characteristics and is of vital significance for bone repair and regenerative medicine. OBJECTIVE： To review the distribution of blood vessels in antler cartilage tissue, the generating process and mechanism of blood vessels, cytokines influncing angiogenesis, and to analyze the features of deer antler models in bone tissue engineering, providing medical reference for bone repair. METHODS： A computer-based online search of Pub Med and CNKI databases was performed using the keywords of ＂deer antler, bone tissue engineering, vascularized cartilage＂ in English and Chinese,respectively. Articles concerning antler histology, morphology, antler cartilage and vascularized cartilage and bone tissue engineering were enrolled and repetitive studies and irrelevant articles were excluded. RESULTS AND CONCLUSION： Fifty-one eligible articles were selected finally. Deer antler is a kind of periodic regenerative bone, and antler cartilage is different from normal cartilage that is rich in blood vessels with the growth speed of 2.7 cm/day. Scholars have studied the vascularization of antler cartilage tissue, and obtained some achievements. Exploring the distribution of antler blood vessels in cartilage tissue, the generating process and mechanism of antler blood vessels, the cytokines acting on antler angiogenesis, as well as analyzing the advantages of deer antler model for bone tissue engineering provide a reference for tissue-engineered cartilage vascularization.

关 键 词：新生血管化 生理性 细胞因子类 软骨 组织工程 组织构建 骨组织工程 鹿茸 血管 血管化 细胞因子 软骨组织 骨修复 综述 吉林省自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]