解剖型表面微孔钛合金椎间融合器的生物相容性  

Biocompatibility of anatomic porous titanium fusion cage

作　　者：阿尖措[1] 王喜民[1] 李占银[1] 许志华[1] 

机构地区：[1]青海红十字医院,青海省西宁市810000

出　　处：《中国组织工程研究》2016年第48期7185-7191,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:传统的带螺纹水平圆柱形钛合金椎间融合器虽能改善腰椎退变疾病患者的症状,但患者预后较差、椎间融合率较低。目的:研究解剖型表面微孔钛合金椎间融合器生物相容性及在腰椎退变性疾病中的应用效果。方法:将50例腰椎退变性疾病患者随机分为两组,试验组(n=25)采用解剖型表面微孔钛合金椎间融合器进行椎间融合治疗,对照组(n=25)采用传统钛合金椎间融合器进行椎间融合治疗。治疗后随访观察融合率、椎间隙高度比、椎间孔高度比、椎体间角度活动域、融合节段前凸角、腰椎前凸角、腰椎水平角及骶骨水平角。结果与结论:随访6-29个月,试验组骨融合率显著高于对照组(92%,68%,P<0.05),试验组未出现不良反应,对照组3例出现感染、慢性脑脊液漏等并发症;治疗后3,6个月,试验组椎间隙高度比、椎间孔高度比、椎体间角度活动域(L_(3/4)、L_5及L_5/S_1)、融合节段前凸角、腰椎前凸角、腰椎水平角及骶骨水平角显著大于对照组(P均<0.05);结果表明,解剖型表面微孔钛合金椎间融合器置入治疗腰椎退变性疾病具有良好生物相容性,且融合率高。BACKGROUND： Traditional horizontal cylindrical titanium alloy interbody fusion cage with screw thread can improve the symptoms of patients with degenerative lumbar disease, but the prognosis is poor and fusion rate is low. OBJECTIVE： To study the biocompatibility of anatomic porous titanium fusion cage and application effect of degenerative lumbar disease. METHODS： Fifty patients with degenerative lumbar diseases were randomly divided into two groups. Patients in the experimental group（n=25） were treated with anatomic porous titanium fusion cage. Patients in the control group（n=25） were treated with traditional titanium fusion cage. After treatment, fusion rate, intervertebral space height ratio, intervertebral foramen height ratio, inter-vertebral angle activity domain, fusion segment lordosis angle, lumbar lordosis angle, lumbar horizontal angle and sacrohorizontal angle were observed. RESULTS AND CONCLUSION： Patients were followed up for 6 to 29 months. Fusion rate was significantly higher in the experimental group than in the control group（92%, 68%; P〈0.05）. No adverse reactions were seen in the experimental group. Infection and chronic cerebrospinal fluid leakage were found in three cases of the control group. At 3 and 6 months after treatment, intervertebral space height ratio, intervertebral foramen height ratio, inter-vertebral angle activity domain（L（3/4）, L（5/5） and L5/S1）, fusion segment lordosis angle, lumbar lordosis angle, lumbar horizontal angle and sacrohorizontal angle were significantly larger in the experimental group than in the control group（all P〈0.05）. These results suggest that anatomic porous titanium fusion cage for treating degenerative lumbar disease has good biocompatibility, and the fusion rate is high.

关 键 词：合金 脊柱融合术 组织工程 骨科植入物 脊柱植入物 解剖型表面微孔钛合金椎间融合器 生物相容性 腰椎退变性疾病 应用效果 传统融合器 椎间隙高度比 椎间孔高度比 节段前凸角 融合率 

分 类 号：R318[医药卫生—生物医学工程]