可溶性纤维介素2的免疫调节作用研究进展  

Research progress on the role of soluble fibrinogen-like protein 2 in immunoregulation

作　　者：彭博[1,2] 戎瑞明[1,2] 许明[1,2] 朱同玉[1,2] 

机构地区：[1]复旦大学附属中山医院泌尿外科,上海200032 [2]上海市器官移植重点实验室,上海200032

出　　处：《中国临床医学》2016年第5期656-661,共6页Chinese Journal of Clinical Medicine

摘　　要：可溶性纤维介素2(soluble fibrinogen-like protein 2/fibroleukin,sFGL2)是调节性T细胞(regulatory T cells Treg)分泌的效应分子,具有免疫调节作用,对维持Treg的活性及功能十分重要。sFGL2还可以通过FcγRIIB受体,抑制树突状细胞的成熟,诱导B细胞凋亡,抑制T细胞的活化增殖,有望作为预防和治疗排斥反应、诱导免疫耐受的新型药物。文中总结了近年来关于sFGL2免疫调节作用的研究进展,介绍了sFGL2的结构、受体、与T细胞及抗原递呈细胞的关系以及相关的信号通路,并探讨了sFGL2在器官移植中的作用及临床应用的可能。Soluble fibrinogen-like protein 2（sFGL2）,or fibroleukin,is an effector secreted by the regulatory T cells（Treg）and plays an important role in immunoregulation.It is critical for the maintenance of the activity and function of Treg,and can suppress the maturation of dendritic cells,induce the apoptosis of B cells and suppress the activation and proliferation of T cells through the FcγRIIB receptor,so that it is a promising drug for prevention and treatment of rejection,and induction of immune tolerance.This review concluded the recent progress of immunoregulatory research of sFGL2,including its structure and receptor,its effects on T cells and antigen presenting cells,its signaling pathway,its relationship with organ transplantation and its possibility for clinic use.

关 键 词：可溶性纤维介素2 调节性T细胞 免疫调节 器官移植 

分 类 号：R392.4[医药卫生—免疫学]