STAT3蛋白调节Th17细胞的分化及其与自身免疫相关性血液疾病的关系  

STAT3 in regulating Th17 differentiation and its relationship with autoimmune hematological diseases

作　　者：柯杨[1] 程韵枫[1] 

机构地区：[1]复旦大学附属中山医院血液科,上海200032

出　　处：《中国临床医学》2016年第5期662-666,共5页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(81170473;81470282)~~

摘　　要：信号转导和转录激活因子(signal transducer and activator of transcription,STAT)主要参与细胞信号转导。其中,STAT3蛋白在辅助性T细胞17(T helper cell 17,Th17细胞)的分化中起重要的作用。STAT3信号通路的异常也被证实与多种自身免疫相关性血液疾病的发生相关,如免疫性血小板减少症(immune thrombocytopenia,ITP)、再生障碍性贫血(aplastic anemia,AA)、自身免疫性溶血性贫血(autoimmune hemolytic anemia,AIHA)等。本文就STAT3蛋白与Th17细胞的分化及其与自身免疫相关性血液疾病的关系作一综述。Signal transducers and activators of transcription（STAT）are mainly involved in cellular signal transduction.Among them,STAT3 is particularly important in promoting the differentiation of Th17 cells.Aberrant activation of STAT3 signaling pathway has been confirmed to be related to a number of autoimmune hematological diseases,such as immune thrombocytopenia（ITP）,aplastic anemia（AA）,and autoimmune hemolytic anemia（AIHA）.This paper has reviewed the relationship between STAT3,Th17 cell differentiation and autoimmune hematological diseases.

关 键 词：STAT3 TH17细胞 自身免疫相关性血液疾病 

分 类 号：R558[医药卫生—血液循环系统疾病]