原发免疫性血小板减少症中调节性T淋巴细胞的异常  

Abnormalities of regulatory T lymphocytes in primary immune thrombocytopenia

作　　者：卢雨萌 程韵枫[1] 

机构地区：[1]复旦大学附属中山医院血液科,上海200032

出　　处：《中国临床医学》2016年第5期672-676,共5页Chinese Journal of Clinical Medicine

摘　　要：原发免疫性血小板减少症(immune thrombocytopenia,ITP)是一种自身免疫性疾病,表现为血小板减少和出血风险增加。除了自身反应性B细胞产生的血小板自身抗体对血小板的破坏以及Th1/Th2细胞的失衡外,对调节性T淋巴细胞的研究也越来越引起重视。经典的调节性T淋巴细胞是CD4^+T淋巴细胞的一个亚群,能抑制免疫反应。而最近研究发现CD8^+的调节性T淋巴细胞也与ITP发病和治疗有关。现着眼于调节性T淋巴细胞数量与功能的异常在ITP发病机制中发挥的作用做一综述。Primary immune thrombocytopenia is a kind of autoimmune disease,characterized by decreased platelets and an increased risk of bleeding.Besides destruction of platelet by platelet specific antibodies produced by auto-reactive B cells and the imbalance of Th1/Th2 cells,the study of regulatory T lymphocytes is getting more and more attention.Regulatory T lymphocytes are a subset of CD4~＋T lymphocytes that can suppress immune response.However,recent studies have discovered that a sublineage of CD8~＋regulatory T lymphocytes is also associated with the pathogenesis and treatment of ITP.This review focuses on the role of abnormalities in the number and function of regulatory T lymphocytes in the pathogenesis of ITP.

关 键 词：免疫性血小板减少症 发病机制 调节性T淋巴细胞 

分 类 号：R558.2[医药卫生—血液循环系统疾病]