结核感染T细胞检测在结核感染相关皮肤病的应用价值  

Application value of T-SPOT.TB assay in tuberculous infection-related skin diseases

作　　者：陈燕清[1] 陈志明[1] 姜海琴[1] 王洪生[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所分枝杆菌实验室,南京210042

出　　处：《国际皮肤性病学杂志》2016年第6期472-474,共3页International Journal of Dermatology and Venereology

摘　　要：结核病常用的实验室检测方法,包括抗酸染色涂片镜检、组织分离培养、组织病理、PCR检测等.结核感染T细胞检测是实验室检测结核病较新的辅助手段,属γ干扰素释放试验的一种,现已被越来越广泛地应用于临床.回顾结核感染T细胞检测的原理、特性及结核感染T细胞检测在诊断皮肤结核、探讨与结核感染相关的皮肤病的发病机制、药物治疗前评估潜伏结核激活的风险等方面的应用价值.Common laboratory assays for the diagnosis of tuberculosis include acid-fast smear,tissue culture,histopathological study,PCR,and so on.T-SPOT.TB assay,a new auxiliary laboratory method for tuberculosis diagnosis,belongs to interferon-gamma release assays,and has been more and more widely applied in clinical practice.This review summarizes the principles and characteristics of T-SPOT.TB assay,as well as its application values in diagnosing cutaneous tuberculosis,exploring the pathogenesis of tuberculous infection-related skin diseases,and in evaluating the risk of latent tuberculosis activation before medical treatments.

关 键 词：结核 皮肤 结核 潜伏性结核 方法 Γ干扰素释放试验 结核感染T细胞检测 

分 类 号：R529.4[医药卫生—内科学]