TPFI-2、VEGF在EBUS-TBNA获取非小细胞肺癌患者转移淋巴结中的表达及相关性研究  

Expression and Clinical Significance of TPFI-2 and VEGF in Metastatic Lymph Nodes of Non-small Cell Lung Cancer by EBUSTBNA

作　　者：刘振丽[1] 张广宁[1] 山凤莲[1] 王全义[1] 武薇[1] 刘艳[1] 李钊[1] 

机构地区：[1]济宁医学院附属医院呼吸内科,山东济宁272100

出　　处：《中国继续医学教育》2016年第33期69-70,共2页China Continuing Medical Education

摘　　要：目的探讨TPFI-2、VEGF在EBUS-TBNA获取非小细胞肺癌患者转移淋巴结中的表达及相关性。方法运用EBUS-TBNA技术获取非小细胞肺癌患者纵隔、肺门转移淋巴结组织标本40例及非转移肿大淋巴结组织标本10例,通过免疫组化检测其中的TFPI-2、VEGF表达,同时测定MVD,进行相关因素分析。结果非小细胞肺癌转移淋巴结中:(1)TFPI-2、VEGF的表达水平与患者吸烟指数、肺癌临床分期、是否有淋巴结转移有关(P<0.05);(2)TFPI-2与VEGF表达呈负相关(P<0.05);(3)高、低MVD组中的TFPI-2、VEGF阳性表达率存在明显差异(P<0.05)。结论非小细胞肺癌转移淋巴结中TFPI-2、VEGF的表达与吸烟、TNM分期、淋巴结转移、MVD有关,且TFPI-2可能通过下调VEGF表达来抑制非小细胞肺癌肿瘤新生血管的形成。Objective To explore the expression and clinical significance of TPFI-2 and VEGF in metastatic lymph nodes of Non-small cell lung cancer by EBUS-TBNA. Methods Obtained 40 specimen of mediastinal lymph nodes and hilar lymph node and 10 specimen of non-MLPN of Nonsmall cell lung cancer by EBUS-TBNA. Detected the TPFI-2, VEGF and MVD by immunohis-to-chemistry examine and taken correlation factor analysis. Results In metastatic lymph nodes of Non-small cell lung cancer：（1） The expression level of TPFI-2 and VEGF was related to smoking index, clinical staging of lung cancer and lymph node metastasis（P〈0.05）.（2） Significant negative correlation was found between TPFI-2 and VEGF（P〈0.05）.（3） There was significant difference of positive rate of TPFI-2 and VEGF between high MVD group and low MVD group（P〈0.05）. Conclusion The expression level of TPFI-2 and VEGF in metastatic lymph nodes of Non-small cell lung cancer was related to smoking index, clinical staging, lymph node metastasis and MVD. TPFI-2 can inhibit the start of neovascularization in non-small cell lung cancer by the decrease of VEGF.

关 键 词：TPFI-2 VEGF EBUS-TBNA 非小细胞肺癌 转移淋巴结 

分 类 号：G643[文化科学—高等教育学]