3，4-二乙酰氧基-α-乙酰氧基苯基丙酸的合成  

作　　者：张微[1] 李荣杰[2] 

机构地区：[1]内蒙古医科大学新药安全评价研究中心,呼和浩特010110 [2]内蒙古医科大学附属医院药剂部,呼和浩特010050

出　　处：《北方药学》2016年第12期118-118,177,共2页Journal of North Pharmacy

摘　　要：丹参素作为治疗心脑血管疾病的药物,疗效确切。在已上市的丹参制剂中,丹参素皆为天然提取物,来源有限,限制了丹参素的推广。本文以近年来国内外论文及专利为依据,合成得到了结构稳定的3,4-二乙酰氧基-α-乙酰氧基苯基丙酸,为丹参素的进一步设计和研究提供理论依据。Danshensu has curative effects as a drug for the treatment of cardiovascular and cerebrovascular diseases. The small amounts of Danshensu in Salvia mihiorrhiza limited its application. This review summarizes the chemical synthesis and structural modification of Danshensu and its derivatives based on the papers and patents published in resent years and may provides a reference for further structural optimization of Danshensu and innovation of new durgs.

关 键 词：丹参素 合成 方法改进 

分 类 号：R284.3[医药卫生—中药学]