静息心率与代谢综合征关系的队列研究  

Association between resting heart rate and metabolic syndrome： a cohort study

作　　者：韩成义 罗新萍[2] 张明[2] 张璐[1] 任永成[1] 王炳源[1] 张红艳[1] 杨香玉[1] 周俊梅[2] 赵阳[1] 刘雪娇[1] 张冬冬[1] 李琳琳[1] 王重建[1] 尹磊 庞超 冯天平 赵景志 胡东生[1] Han Chengyi Luo Xinping Zhang Ming Zhang Lu Ren Yongcheng Wang Bingyuan Zhang Hongyan Yang Xiangyu Zhou Junmei Zhao Yang Liu Xuejiao Zhang Dongdong Li Linlin Wang Chongjian Yin Lei Pang Chao Feng Tianping Zhao Jingzhi Hu Dongsheng(Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen 518060, China Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou 450003, China)

机构地区：[1]郑州大学公共卫生学院流行病与卫生统计学系,450001 [2]深圳大学医学部预防医学系,518060 [3]河南省军区医院预防保健科,郑州450003

出　　处：《中华流行病学杂志》2016年第12期1653-1657,共5页Chinese Journal of Epidemiology

基　　金：国家自然科学基金（81373074,81402752）

摘　　要：目的 探讨静息心率（RHR）与MS发病的关系。方法 采用整群抽样方法，选择河南省某农村地区≥18岁常住居民为研究对象。2007年7-8月和2008年7-8月进行问卷调查、体格检查、血糖及脂质谱检测。2013年7-8月和2014年7-10月进行与基线相同内容的随访。结果 在平均6年的随访期间，MS累积患病率为21.89%（1 933/8 829），其中男性为16.78%（664/3 957），女性为26.05%（1 269/4 872）；控制潜在的混杂因素后，以基线RHR〈60次/min组为参照，RHR 60～69、70～79、80～89和≥90次/min组发生MS的OR值（95%CI）分别为1.24（0.95～1.60）、1.42（1.10～1.84）、1.63（1.24～2.15）和1.62（1.16～2.27），其中男性分别为1.12（0.81～1.55）、1.23（0.88～1.71）、1.42（0.97～2.07）和1.84（1.09～3.11），女性分别为1.46（0.93～2.29）、1.70（1.09～2.65）、1.99（1.25～3.16）和1.78（1.06～2.98）。结论 女性MS发病风险高于男性且升高的RHR增加MS发病风险。应制定针对RHR升高的成年人群尤其是女性的MS综合干预策略和措施。Objective To investigate the association between resting heart rate （RHR） and subsequent metabolic syndrome （MS）. Methods Under a cluster design, participants age ≥18 years old were selected from a rural area of Henan province in China. Interview through questionnaire, physical examination, fasting blood glucose, and lipid profile measurements were done from July to August of 2007 and July to August of 2008. Same methods were implemented in the follow-up examination, during July to August of 2013 and July to October of 2014. Results During the 6-year follow-up period, cumulative incidence rates of MS for overall, male, and female participants appeared as 21.89%（1 933/8 829）, 16.78%（664/3 957） and 26.05%（1 269/4 872）, respectively. After controlling for potential confounders and compared with the groups of RHR〈60 bpm, 60-69, 70-79, 80-89 and ≥90 bpm, the ORs （95%CIs） of MS for overall, male, and female participants became 1.24（0.95-1.60）, 1.42（1.10-1.84）, 1.63（1.24-2.15） and 1.62（1.16-2.27）; 1.12（0.81-1.55）, 1.23（0.88-1.71）, 1.42（0.97-2.07） and 1.84（1.09-3.11）; 1.46（0.93-2.29）, 1.70（1.09-2.65）, 1.99（1.25-3.16） and 1.78（1.06-2.98）; respectively. Conclusions The risk on MS appeared higher in females than in males while the risk for MS increased with the elevation of RHR. Intensive intervention programs that targeted adult participants with elevated RHR, especially in females, should be formulated and implemented.

关 键 词：静息心率 代谢综合征 队列研究 

分 类 号：R589[医药卫生—内分泌]