醋酸锌催化串联反应合成2-氨基-3-氰基-4H-吡喃衍生物  

Syntheses of 2-Amino-3-cyano-4H-pyran Derivatives Catalyzed by Zinc Acetate

作　　者：吴小云[1] 尹晓刚[1] 龚维[1] 陈治明[1] 陈卓[1] 

机构地区：[1]贵州师范大学化学与材料科学学院贵州省功能材料化学重点实验室,贵阳550001

出　　处：《化学通报》2016年第12期1156-1160,共5页Chemistry

基　　金：国家自然科学基金项目(21362006);贵州省科学技术基金项目(黔科合J字[2014]2129);贵州省科技创新人才团队建设项目(黔科合人才团队[2014]4006号)资助

摘　　要：以氰基查尔酮类化合物及丙二腈为原料,醋酸锌为催化剂,经串联反应合成了一系列2-氨基-4H-吡喃类衍生物。考察了催化剂、溶剂、反应时间及温度、原料摩尔比对产率的影响。确定的优化反应条件为:氰基查尔酮类化合物与丙二腈摩尔比为1∶1,醋酸锌(10(mol)%))作催化剂,二氯甲烷作溶剂,反应温度为30℃。此条件下,最高产率可达99.5%。2-Amino-4H-pyran derivatives were synthesized under the catalysis of zinc acetate using cyano ehalcones and malononitrile as raw materials. Influenees of catalysts, solvents, reaction time and temperature, mole ratio of raw material on the yield were studied. The optimal conditions are as follows, molar ratio of cyano chalcones and malononitrile is 1 ： 1, zinc acetate （10（mol）%） as catalyst, methylene chloride as solvent, the reaction temperature is 30℃. Under this condition, the highest yield of target product can reach 99.5%.

关 键 词：醋酸锌 串联反应 2-氨基-3-氰基-4H-吡喃衍生物 

分 类 号：O621.251[理学—有机化学]