弥散张量成像在新生儿脑发育及脑损伤中的应用  

Application of diffusion tensor imaging in the neonatal brain development and injury

作　　者：王欣瑞[1] 沈瑾[2] 李志华[1] 

机构地区：[1]复旦大学附属儿科医院新生儿科,上海201102 [2]复旦大学附属儿科医院放射科,上海201102

出　　处：《中华实用儿科临床杂志》2016年第23期1838-1840,共3页Chinese Journal of Applied Clinical Pediatrics

摘　　要：弥散张量成像（DTI）通过获得组织中水分子弥散大小和方向的信息，能够更加量化、直观地反映组织的结构特性及发育变化。在脑发育研究中，DTI可反映婴幼儿脑组织特别是白质纤维束的发育规律、评价脑结构发育畸形、探索白质微结构与神经发育结局的关系。在早产儿脑白质损伤、缺氧缺血性脑病、脑梗死等疾病中，DTI能更精确地诊断脑组织微结构损伤、评价干预措施效果及协助预测远期神经系统发育结局。总之，DTI在新生儿脑发育及脑损伤性疾病的研究和临床诊疗中有较好的应用前景。Diffusion tensor imaging （DTI） can reflect the brain structure and development more quantitatively and intuitively than conventional magnetic resonance sequence by obtaining the diffusion properties of water molecules.In neonatal brain developmental research, DTI could be used to study the developmental regularities of white matter tracts and cerebral structure deformity.It can also help to explore the relationship between white matter microstructure and neurodevelopmental outcome.In the study of brain injury, including premature white matter injury, hypoxic ischemic encephalopathy, neonatal stroke, and so on, DTI can diagnose the brain microstructure injury precisely, evaluate the effectiveness of interventions and predict the long-term neurodevelopmental outcome.DTI may have good prospect in research and clinical application on neonatal brain development and injury.

关 键 词：弥散张量成像 婴儿 新生 脑发育 脑损伤 

分 类 号：R722.1[医药卫生—儿科]