Electrochemical Determination of Dapoxetine HCI in Biological Fluids Using Coated Wire Electrode  

作　　者：Amani Salim Alturiqi 

机构地区：[1]Department of Chemistry, College of Science, Princess Nourah Bint Abdul Rahman University, AI Riyadh, Saudi Arabia

出　　处：《Journal of Chemistry and Chemical Engineering》2016年第6期277-282,共6页化学与化工（英文版）

摘　　要：Coated wire sensor for potentiometric determination ofDAP （dapoxetine HCI） in pure form and in biological fluidsbased on DAP-TPB （dapoxetine-tetraphenyl borate） as the sensing element in the presence of DOP （dioctylphthalate） as the plasticizing solvent mediator was prepared. The best performance was obtained with a membrane composition of 10.0% （w/w） ion-pair, 45.0% DOP （w/w） and 45.0% PVC （w/w）. The electrode showed a Nemstian response （with a slope of 58.70 mV decade-1） for the concentration range of 4.2 × 10-5-1.0 ×10-2 mol/L. It illustrates a relatively fast response time in the whole concentration range （-15 s） in a pH range of 3.0-7.5. The selectivity coefficients were determined in relation to several inorganic and organic species. DAP is determined successfully in pure solutions and in biological fuids using the standard additions and petentiometric titrations methods.

关 键 词：DAP coated wire electrode biological fluids. 

分 类 号：TQ153[化学工程—电化学工业] X592[环境科学与工程—环境工程]