药用植物生物碱次生代谢工程研究进展  

Advances in study on secondary metabolic engineering of alkaloids in medicinal plants

作　　者：黄玉香[1,2,3] 谭何新[3] 于剑[3] 张青磊[2,3] 郭志英[2,3] 陈越[2,3] 刁勇[2] 张磊[3] 

机构地区：[1]泉州医学高等专科学校药学院,福建泉州362000 [2]华侨大学生物医学学院,福建泉州362000 [3]中国人民解放军第二军医大学药学院,上海200433

出　　处：《中草药》2016年第23期4271-4281,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金联合基金项目(U1405215);福建省卫生教育联合攻关计划项目(WKJ-FJ-13);泉州市优秀人才培养专项(15A22);泉州市科技计划项目(2016Z006;2016Z075)

摘　　要：药用植物次生代谢途径及其调控机制的研究基础薄弱,阻碍了代谢工程在获取高价值次生代谢产物的广泛应用。生物碱是存在于药用植物中的一类含氮杂环化合物,具有抗肿瘤、抗微生物、降血压、解痉镇痛等药理作用,备受研究者的关注。应用代谢工程手段改善代谢途径,提高次生代谢产物的量,对优化药用植物种质资源以及可持续发展具有重要价值。通过对药用植物生物碱类化合物的代谢合成途径进行综述,并讨论生物碱代谢工程的研究方法和调控策略,为药用植物生物碱相关研究提供参考。Since the weak research basis on metabolic pathway and regulation mechanism of medicinal plants,obtaining valuable secondary metabolites from medicinal plants by metabolic engineering technology is seriously impacted.Alkaloids are nitrogen heterocyclic compounds in medicinal plants,which have pharmacological effects,such as anti-tumor,anti-microbial,anti-hypotensive,spasmolysis analgesia,etc.It is valuable for optimizing the germplasm resource of medicinal plants and their sustainable development by using metabolic engineering methods to influence the metabolic pathways in order to increase the content of secondary metabolites.The synthetic metabolic pathways about alkaloids of medicinal plants were reviewed in this paper,as well as research methods and regulation strategies,for giving some references to relative studies on alkaloids from medicinal plants.

关 键 词：药用植物 生物碱 合成途径 次生代谢 代谢调控 

分 类 号：R282.1[医药卫生—中药学]