过氧化氢探针的研究进展  

Research Progress of Molecular Probe for Hydrogen Peroxide

作　　者：翁金鹏 蒋刚锋 刘明哲[1] 

机构地区：[1]沈阳药科大学制药工程学院,沈阳110016

出　　处：《材料导报（纳米与新材料专辑）》2016年第2期111-115,共5页

基　　金：辽宁省自然科学基金(2015020755)

摘　　要：作为活性氧家族中的重要成员,过氧化氢不仅是生命体内重要的氧代谢产物和信号传导介质,而且也是氧化胁迫的主要来源和活性氧相关疾病的重要标志物。因此,开发快速、简便、灵敏的过氧化氢探针材料在生物医学等领域具有重要的意义。过氧化氢探针可分为荧光探针、生物发光探针、电极探针等,其中荧光探针因具有高灵敏度、高选择性等特点而受到广泛的关注。以荧光探针为中心,根据分子的大小和工作原理的不同进行分类,介绍了过氧化氢探针的研究进展,并对过氧化氢探针的发展前景进行了展望。As a major reactive oxygen species （ROS）, hydrogen peroxide is not only an essential oxygen meta- bolite and second messenger in living organism, but also major source of oxidative stress and marker of ROS related disease. Therefore, development of a new molecular probe for rapid, simple and sensitive hydrogen peroxide-sensing is an important subject in biomedicine field. Hydrogen peroxide probes can be classified into fluorescence probes, biolu- minescent probes, electrode probes and so on. Among these, fluorescence probe received great attention because of its high sensitivity and selectivity. In this review, recent research progress on hydrogen peroxide probes is summarized and introduced according to their molecular size and working principle. Finally, the application prospect of hydrogen peroxide probes is also discussed.

关 键 词：过氧化氢 探针 传感器 分子成像 纳米粒 活细胞 体内 

分 类 号：O62[理学—有机化学]