慢性乙醇中毒性周围神经病电生理特征及执行功能的对照研究  

Control study on electrophysiological characteristics and executive function of chronic alcoholism peripheral neuropathy

作　　者：李晨[1] 李经纶[2] 黄立桂[3] 

机构地区：[1]解放军第153中心医院神经内科,450042 [2]解放军第153中心医院全军微创神经外科临床中心,450042 [3]解放军南京军区杭州疗养院全军创伤康复中心,310007

出　　处：《中国疗养医学》2017年第1期5-8,共4页Chinese Journal of Convalescent Medicine

基　　金：全军十二五重点项目(BWS11J025)资助课题"周围神经损伤及修复的微观机制"

摘　　要：目的研究慢性乙醇中毒性周围神经病(CAPN)的神经电生理异常及脑执行功能。方法以CAPN患者为研究组,同时期健康志愿者为对照组,测定神经传导速度、动作电位潜伏期及波幅、尺神经F波、胫神经H反射,测定ODDBELL、STERBERG、双重视听任务的反应时间、正确率及追踪误差。结果 171.95%的CAPN患者存在神经电生理学异常。2所有CAPN患者的神经传导速度均显著偏低(t=10.186~30.143,P=0.000 0),动作电位潜伏期延长(t=7.299~31.806,P=0.000 0),动作电位波幅偏低(t=6.307~32.792,P=0.000 0)。3CAPN患者的任务反应时间显著延长(t=16.588~16.892,P=0.000 0),正确率显著偏低(t=8.499~23.782,P=0.000 0)。结论 CAPN患者在中枢神经系统临床表现出现前,已经存在脑部高级智能活动障碍,神经心理学检查有助于其早期诊断。Objective To study the neuroprotenial abnormality and brain executive function of Chronic Alcoholism Peripheral Neuropathy（CAPN）.Mothods CAPN sufferers were involved in the study group, and the healthy volunteers were taken as the control group.The nerve conduction velocity of peripheral nervous system,the delitescence and am- plitude of action potential, the F wave of ulnar nerve, and the H reflex of tibial nerve were detected in both groups, moreover the response time and correct rate in ODDBELL task, STERBERG task, and dual seeing and hearing task and tracking error were detected.Results （1）Neuroprotenial abnormality occurred in 71.95% of the CAPN sufferers.（2）Nerve conduction velocity of all CAPN sufferers was clearly low（t= 10.186～30.143, P=0.000 0）,the delitescence of action potential prolonged （t =7.299 ～31.806, P =0.000 0）, and the amplitude of action potential flatted （t = 6.307 ～32.792, P = 0.000 0）. （3） The task response time of the CAPN sufferers clearly was prolonged （t = 16.588 ～16.892, P = 0.000 0）, and the task correct rate was clearly lowered （t = 8.499 ～23.782, P = 0.000 0）. Conclusion There are advanced intelligent activity obstacles in brains before the clinical manifestation of central nervous system in sufferers with chronic alcoholism peripheral neuropathy, and the rigorous neuropsychology examination can help with the early diagnosis.

关 键 词：神经心理学 神经电生理学 周围神经病 慢性乙醇中毒 执行功能 

分 类 号：R595.6[医药卫生—内科学] R745[医药卫生—临床医学]