通痹汤对二硝基氟苯诱导大鼠的免疫调节作用  

Immune Function Regulation Effect of Tongbi Decoction on Rat Induced by Dinitrofluorobenzene

作　　者：余艺萍[1] 杨军平[1] 肖伟平[1] 刘萍[2] 

机构地区：[1]江西中医药大学附属医院,南昌330006 [2]南昌大学,南昌330031

出　　处：《江西中医药大学学报》2016年第6期71-73,共3页Journal of Jiangxi University of Chinese Medicine

基　　金：国家自然科学基金项目(81460769)

摘　　要：目的:研究通痹汤对二硝基氟苯诱导的大鼠迟发型变态反应的作用,探讨其对佐剂性关节炎(AA)大鼠免疫功能的影响。方法:选用大鼠70只,随机分为七组,每组10只,先将60只造成佐剂性关节炎模型,用2,4—二硝基氟苯对其进行致敏,观察给药前后各组大鼠的右后足垫、耳肿胀度、脾脏指数、胸腺指数以及血清Ig G和Ig M水平。结果:通痹汤不同剂量组大鼠的脾脏指数与模型对照组相比有显著性差异(P<0.01);通痹汤大剂量组大鼠耳肿胀值与模型对照组相比有显著性差异(P<0.01);通痹汤大剂量组大鼠血清Ig G与模型对照组相比有显著性差异(P<0.01);通痹汤各剂量组血清Ig M水平与模型对照组相比有显著性差异(P<0.01)。结论:通痹汤能够显著抑制佐剂性关节炎大鼠迟发性变态反应和体液免疫功能,其治疗类风湿关节炎的机制可能与调节体内免疫反应有关。Objective： The study focused on Tong Bi decoction to ruduce rat delayed hypersensitivity reaction induced by dinitrofluorobenzene,to investigate its effects on immune function in adjuvant arthritis rats. Method： 70 rats were randomly divided into 7 groups,each group had 10 rats,and 60 rats were induced by adjuvant arthritis model,The sensitized with 2／4-dinitrofluorobenzene,Observed before and after administration of the rats right foot pad,ear swelling,spleen index,thymus index and serum Ig G and Ig M levels. Results： spleen index of different dose group rat of Tong Bi decoction was markedly lower than that of model group（P〈0. 01）,high dose Tong Bi decoction can make the adjuvant arthritis rat ear swelling was significantly reduced（P〈0. 01）,the master of the serum Ig G decreased obviously（P〈0. 01） compared with the control group,the level of Tong Bi-decoction with different doses of Ig G group decreased significantly（P〈0. 01） compared with the control group. Conclusion： The Tong Bi-decoction can significantly inhibit the delayed allergic reaction and humoral immune function of adjuvant arthritis rats,and the mechanism of the treatment of rheumatoid arthritis may be related to the regulation of immune response.

关 键 词：通痹汤 佐剂性关节炎 免疫调节 

分 类 号：R285.5[医药卫生—中药学]