气道黏液高分泌机制的研究进展  

Research progress of mucus high-secretion mechanisms in airway

作　　者：陈玉梅[1] 童瑾[1] 

机构地区：[1]重庆医科大学附属第二医院呼吸内科,重庆400010

出　　处：《基础医学与临床》2016年第11期1573-1577,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(81400004)

摘　　要：气道黏液高分泌主要表现为气道黏液理化性质的改变,包括以MUC5AC为主的黏液组分改变和由黏液腺细胞为主过渡到以杯状细胞为主的分泌黏液细胞的改变。香烟烟雾为主的吸入性有害物和细菌感染是诱导气道黏液高分泌的主要刺激物,而热休克蛋白、信号传导通路和黏蛋白MUC5AC表达的增加是气道黏液高分泌的主要机制。High airway mucus secretion is mainly characterized by the changes of airway mucus in the physicochemical property,including the changes of mucus components which are mainly changed with MUC5 AC and mucous secretory cells which are mainly changed from mucus cells to goblet cells. The harmful inhalation substance mainly in cigarette smoke and bacterial infection are the main irritants to induce the high airway mucus secretion. Besides,heat shock protein,signal transduction pathway and the increase of MUC5 AC expression are the major mechanisms of high airway mucus secretion.

关 键 词：气道黏液高分泌 慢性气道炎性反应 黏蛋白 

分 类 号：R56[医药卫生—呼吸系统]