桑黄成分及其抗肿瘤作用机制研究进展  

Progress in the study of composition and mechanism of antitumor effect of Phellinus igniarius

作　　者：孙佳琦[1] 张甘霖[1] 于明薇[1] 王笑民[1] 

机构地区：[1]首都医科大学附属北京中医医院肿瘤科,北京100010

出　　处：《中国医药导报》2016年第33期39-42,47,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(81473643);北京市自然科学基金资助项目(7122083)

摘　　要：桑黄是一种名贵的中药材,近年研究发现其抗肿瘤作用明显。总结国内外已发表的有关桑黄及其提取物关于肿瘤的实验研究,发现桑黄主要是通过抗突变预防肿瘤的发生,通过促凋亡、阻滞周期、调节免疫、抗氧化、抑制血管生成的途径抑制肿瘤细胞增殖、侵袭、转移,延长生存期。与化疗药联合应用起减毒增效的作用。本文综述桑黄各种成分提取物及其抗肿瘤作用机制,为进一步研究桑黄抗肿瘤机制奠定基础。Phelinus igniarius is a kind of rare Chinese traditional medicine. Many studies are conducted about its antineoplastic effects in recent years. To summarize the published studies about Phelinus igniarius and its extracts antineo- plastic at home and abroad, and found Phelinus igniarius preventing tumor by anti-mutation, inhibit tumor proliferation, invasion and metastasis, prolong survival by inducing apoptosis, arresting cell cycle, regulating immunity, anti-oxidation, antiangiogenesis. Phelim igniarius with chemotherapy can enhance the effects of chemotherapy and alleviate the drug toxicity. This review summarizes the various kinds of PheUinus igniarius ingredients extractions and its antitumor effect mechanism. Lay the foundation for further study on the antitumor mechanism of Phellinus igniarius.

关 键 词：桑黄 肿瘤 多糖 Hispolon 

分 类 号：R961[医药卫生—药理学]