变应性鼻炎重塑及相关因子的研究  

Research on remodeling and related factors of allergic rhinitis

作　　者：张青萍[1] 许昱[1] 

机构地区：[1]武汉大学人民医院耳鼻咽喉头颈外科,湖北武汉430060

出　　处：《中国医药导报》2016年第33期43-47,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(81371070);湖北省自然科学基金项目(2012FFB04320;2013CKB006)

摘　　要：变应性鼻炎与支气管哮喘均属于呼吸道炎症疾病,由Ig E介导、嗜酸粒细胞数量在气道显著增加为其病理生理特点,两者有相似且交叉的发病机制及临床治疗,流行病学上两者的发病率密切相关,基于"同一气道、同一疾病"的观点,在支气管哮喘重塑研究的基础上,变应性鼻炎是否存在重塑尚有争议,本文总结变应性鼻炎在流行病学上与哮喘的关系,鼻黏膜在变应原长期刺激下的重塑(包括上皮细胞、基底膜厚度、血管及黏液腺的改变)及在重塑研究中可能起重要作用的细胞因子,更加全面且深入地研究变应性鼻炎,旨在为临床治疗变应性鼻炎提供一条新策略及途径。Allergic rhinitis and bronehial asthma are respiratory inflammatory diseases mediated by IgE, the number of eosinophils in the airway was significantly increased as the pathological and physiological characteristics, the two have similar and cross the pathogenesis and clinical treatment, epidemiologieal study on the incidence of the two closely linked,based on the ＂one airway, one disease＂ point of view, the study of remodeling on bronchial asthma is comprehensive, allergic rhinitis remodeling remains controversial, this article aims to summarize the relationship between allergic rhinitis and asthma in the epidemiology, remodeling of the nasal mueosa in long-term allergen stimulated （including epithelial cells, basement membrane thickness, vascular and glandulae mueosa changes） and the eytokines may play an important role in the remodeling of the nasal mueosa, more comprehensive and in-depth study of allergic rhinitis, and provide a new strategy and approach for the treatment of allergic rhinitis.

关 键 词：变应性鼻炎 重塑 支气管哮喘 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]