醋氯芬酸-羧基化多壁碳纳米管电反应透皮给药系统的研制  

Preparation of Aceclofenac-carboxylated Multiwalled Carbon Nanotubes Electro-responsive Transdermal Drug Delivery System

作　　者：崔明汉 邓亚利[2] 

机构地区：[1]华南农业大学,广东广州510642 [2]华南农业大学制药工程系,广东广州510642

出　　处：《中国医药工业杂志》2016年第12期1530-1535,共6页Chinese Journal of Pharmaceuticals

基　　金：广东省科技计划项目(2012B061700094);广东省中医药局项目(20151310)

摘　　要：采用超声法或球磨法制备羧基化多壁碳纳米管,并用傅里叶红外光谱(FTIR)、热重分析(TGA)、拉曼光谱进行表征。比较了分别采用振荡吸附法、冷冻球磨吸附法与超声吸附法时羧基化多壁碳纳米管对醋氯芬酸吸附量的影响,结果显示采用冷冻球磨吸附法时药物吸附量最高。采用Franz扩散池法,分别以透析膜、小鼠离体皮肤为屏障,考察了醋氯芬酸凝胶及其羧基化多壁碳纳米管复合物凝胶的透皮行为,并考察与离子导入法联用后透皮速率的变化。结果显示,羧基化碳纳米管提高了药物的透皮速率,但时滞略增加;联用离子导入法(电流密度分别为0.2、0.3和0.5 mA/cm^2)后,复合物凝胶在快速释放相(1~4 h)的透皮速率相应为3.73、6.21和8.72μg·cm^(-2)·h^(-1)。提示具有良好导电性能的羧基化碳纳米管可作为电反应透皮给药系统载体。Carboxylated multiwalled carbon nanotubes were prepared by ultrasonic method or milling method and characterized by Fourier transform infrared spectroscopy （FTIR）, thermal gravimetric analysis （TGA） and Raman spectroscopy. The effects of different adsorption methods （oscillation method, frozen milling method and ultrasonic method） on aceclofenac adsorption on the prepared carbon nanotubes were investigated. The results showed that the frozen milling method had the best effect. The transdermal behaviors of aceclofenac from the gels loaded with the bulk drug or the complex of aceclofenac-carboxylated multi-walled carbon nanotubes were investigated by Franz diffusion cell method with dialysis membrane and excised mouse skin as barriers. The changes of transdermal rate after combining with iontophoresis were also investigated. The results showed that the transdermal rate of the gels loaded with the complex was improved but the lag time was slightly prolonged. After combining with iontophoresis with current density of 0.2, 0.3 and 0.5 mA/cm^2, the transdermal rates of the complex gels were 3.73, 6.21 and 8.72 μg·cm^-2·h^-1 during the rapid-release phase （1—4 h）. It indicated that carboxylated multi-walled carbon nanotubes could be used as the electro-responsive transdermal drug delivery system due to its good electrical conductivity property.

关 键 词：电反应透皮给药系统 多壁碳纳米管 羧基化 醋氯芬酸 透皮速率 离子导入 

分 类 号：R944.9[医药卫生—药剂学]