丹参注射液对妊高征患者血管内皮及肾功能的影响  

Effect of Danshen injection on the vascular endothelial function and renal function in patients with pregnancy induced hypertension syndrome

作　　者：张俊清[1] 高巍[1] 

机构地区：[1]河北北方学院附属第二医院,河北宣化075000

出　　处：《海南医学院学报》2016年第24期2978-2980,2984,共4页Journal of Hainan Medical University

基　　金：张家口市科学技术研究与发展指导项目(1421105D)~~

摘　　要：目的:探讨丹参注射液对妊娠高血压综合征(PIH)患者血管内皮功能及肾功能的影响。方法:选取PIH患者120例为研究对象,随机分为观察组和对照组,对照组给予降压、利尿、解痉、镇静、硫酸镁等常规治疗及综合护理干预,观察组在对照组基础上联合丹参注射液20mL入5%葡萄糖500mL静脉滴注,1次/d,两组均治疗10d后进行进行效果评价;两组治疗前后分别采集外周静脉血,采用放射免疫法测定内皮素-1(ET-1),酶法测定同型半胱氨酸(Hcy),免疫比浊法测定血管性假血友病因子(vWF);采用放射免疫法测定尿素氮(BUN)、血肌酐(Scr)、尿酸(UA)、β2-微球蛋白(β2-MG);采用标准血压计监测血压,并计算平均动脉压(MAP),双缩脲比色法测定24h尿蛋白(24hUpro)。结果:观察组治疗后ET-1、Hcy、vWF降低程度优于对照组,BUN、Scr、UA、β2-MG降低程度优于对照组,MPA、24hUpro降低程度优于对照组,差异均具有统计学意义(P<0.05)。结论:在常规治疗及综合护理干预下联合丹参注射液治疗PIH,可有效改善患者血管内皮功能及肾功能,从而起到降低血压、减轻尿蛋白的作用。Objective： To explore the effect of Danshen injection on me vascular enuumen in patients with pregnancy induced hypertension syndrome （PIH）. Methods： A total of 120 patients with PIH who were admit- ted in our hospital were included in the study and randomized into the observation group and the control group. The patients in the control group were given blood pressure reduction, diuresis, spasmolysis, sedation, magnesium sulfate, and comprehen- sive nursing intervention. On this basis, the patients in the observation group were given additional Danshen injection （20 mL） _ 5% glucose （250 mL）, iv drip, once per day. After 10-day treatment, the efficacy was evaluated. The peripheral venous blood before and after treatment in the two groups was collected. The radioimmunoassay was used to detect ET-1. ELISA was used to detect Hcy. The immunoturbidimetry was used to detect vWF. The radioimmunoassay was used to detect BUN, Scr, UA, and β2-MG. The standard sphygmomanometer was used to monitor the blood pressure and MAP was calculated. The biu-ret colorimetry was used to determine 24h Upro. Results： The reduced degree of ET-1, Hcy, and vWF after treatment in the observation group was significantly superior to that in the control group （P〈0.05）. The reduced degree of BUN, Scr, UA, and β2-MG after treatment in the observation group was significantly superior to that in the control group （P〈0.05）. The re- duced degree of MPA and 24h Upro after treatment in the observation group was significantly superior to that in the control group （P〈0.05）. Conclusions： Routine treatments, comprehensive nursing intervention, and Danshen injection in the treat- ment of PIH can effectively improve the vascular endothelial function and renal function in order to reduce the blood pressure and alleviate the urine protein.

关 键 词：丹参注射液 妊娠高血压综合征 血管内皮功能 肾功能 

分 类 号：R714.246[医药卫生—妇产科学]