正规抗骨质疏松治疗对原发性骨质疏松症患者骨密度、骨代谢的影响及其与骨折发生的关系  

Effect of regular anti-osteoporosis treatment on bone mineral density and bone metabolism in patients with primary osteoporosis and its relationship with bone fractures

作　　者：钱雪丰[1] 曹平[1] 刘拴[1] 杨洪平[1] 张明勇[1] 

机构地区：[1]武汉科技大学附属天佑医院骨科,湖北武汉430000

出　　处：《海南医学院学报》2016年第24期3020-3023,共4页Journal of Hainan Medical University

基　　金：湖北省科学技术厅项目(EK110281)~~

摘　　要：目的:分析正规抗骨质疏松治疗对原发性骨质疏松症患者骨密度、骨代谢的影响及其与骨折发生的关系。方法:120例原发性骨质疏松症患者纳入本次研究,随机分为观察组及对照组各60例。对照组接受统一治疗,观察组接受个体化正规抗骨质疏松治疗,对比两组治疗1年后骨密度、骨代谢、微量元素、氧化应激、骨折发生率等差异。结果:观察组治疗后BMD绝对值高于对照组;血清骨形成指标骨碱性磷酸酶(ALP)、骨钙素(BGP)、Ⅰ型原胶原N端前肽(PⅠNP)、Ⅰ型前胶原羧基端原肽(PⅠCP)含量高于对照组;血清骨吸收指标Ⅰ型胶原交联C端肽(β-CTX)、破骨细胞分化因子(sRANKL)、抗酒石酸酸性磷酸酶(TRACP)、骨特异性碱性磷酸酶(BAP)、脱氧吡啶啉交联(DPD)含量低于对照组;血清微量元素铁、锌含量高于对照组,钙含量低于对照组;观察组血清中晚期氧化蛋白产物(AOPP)、代谢酶单胺氧化酶A(MAOA)的含量显著低于对照组,超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)的含量显著高于对照组;治疗期间骨折发生率显著低于对照组。结论:正规抗骨质疏松治疗可增加原发性骨质疏松症患者的骨密度、优化整体病情,降低远期骨折发生率。Objective： To analyze the effect of regular anti-osteoporosis treatment on bone mineral density tabolism in patients with primary osteoporosis and its relationship with bone fractures. Methods： A total of 120 and bone me- patients with n=60）. Con- eatment, and ce, and so onwere compared between two groups of patients 1 year after treatment. Results： Absolute t3MD value of observation group after treatment was higher than that of control group; serum bone formation indexes ALP, BGP, P I NP and P I CP content were higher than those of control group;serum bone resorption indexes β-CTX, sRANKL, TRACP, BAP and DPD content were lower than those of control group; serum trace elements iron and zinc content were higher than those of control group while calcium content was lower than that of control group; serum AOPP and MAOA content of observation group were significantly lower than those of control group while SOD and T-AOC content were significantly higher than those of control group ; fracture incidence was significantly lower than that of control group during treatment. Conclusion：The regular anti-osteoporosis treat- ment can increase bone mineral density, optimize the overall condition and reduce the incidence of long-term fracture in patients with primary osteoporosis.

关 键 词：原发性骨质疏松症 抗骨质疏松治疗 骨密度 骨代谢 

分 类 号：R681[医药卫生—骨科学]