糖尿病足创面预后与炎性因子的相关性  

Correlation between the Prognosis of Diabetic Foot Wounds and Inflammation Factor

作　　者：孙好杰[1] 窦连军[1] 龚莹[1] 梁军[1] 

机构地区：[1]东南大学附属医院、徐州市中心医院内分泌科,221000

出　　处：《医学研究杂志》2016年第11期162-164,共3页Journal of Medical Research

摘　　要：目的探讨肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）等炎性因子与糖尿病足创面愈合的关系。方法选取2012年12月～2014年8月在笔者医院内分泌科住院的DF患者共112例，收集临床资料，入院抽血测定TNF-α、IFN-α、IL-6、TGF-β、红细胞沉降率、CRP、白细胞计数、血小板计数，并对结果进行统计分析。结果人组112例患者，男性42例，女性70例，患者平均年龄62±8岁；与愈合组想比，非愈合组的TNF-α、IFN-γ、IL-6、TGF-β、红细胞沉降率、CRP、白细胞计数明显升高，差异有统计学意义（P〈0．05）；单因素Logistic回归分析显示DF病程、HbAlC、DN、严重缺血、TNF-α、IFN-γ、IL-6、TGF-B、红细胞沉降率、CRP、白细胞计数是影响创面愈合的危险因素（P〈0．05）。多因素Logistic回归分析表明，TNF-α、IL-6、红细胞沉降率、白细胞计数、严重缺血是糖尿病足患者创面愈合与否的独立危险因素（P〈0．05）。结论血清TNF-α、IL-6等炎性因子水平升高对糖尿病足创面的愈合中起到重要作用，因此治疗中早期抗感染很有必要。Objective To investigate the relationship of Tumor Necrosis Factor -α,interleukin - 6 and other inflammatory cytokines with the occurrence and development of refractory diabetic foot. Methods Totally 112 inpaticnts with diabetic ankle ulcers were over the period from December 2012 to August 2014. Clinical features were collected. Tumor necrosis factor -α, interferon - γ, interleukin - 6, transforming growth factor - α, erythrocyte sedimentation rate , C - reactive protein ,white blood cell count and hrombocyte from venous blood were determined and analyse. Results There were 112 patients （42 males and 70 females） with an overall mean age of （62 ＋ 8） years. Univariate Logistic regression analysis showed that duration of diabetic foot, HbAI c, DN, critical limb ischemia, tumor necrosis factor - α,interferon - γ,interleukin - 6, transforming growth factor -β, erythrocyte sedimentation rate , C - reactive protein and white blood cell count were risk factors for DF wound healing（ P 〈 0.05 ）. Multivariate Logistic regression analysis showed that only TNF - α, IL - 6, erythrocyte sedimentation rate , white blood cell count and critical limb ischemia were the independent risk factors of DF wound healing（ P 〈 0.05）. Conclusion The elevated levels of serum TNF -α, IL - 6 and other inflammatory cytokines play important roles in the DF wound healing. Early anti - infection, improving ischemia is important.

关 键 词：糖尿病足 炎性因子 感染 

分 类 号：R5[医药卫生—内科学]