乌司他丁联合血必净治疗高原地区与平原地区感染性休克的效果对比分析  

Comparative Analysis of infectious shock Effect of Ulinastatin Combined with Xuebijing Injection in Treatment of Plateau and flat areas

作　　者：刘娟丽[1] 杨正平[1] 马四清[1] 孙斌[1] 石青军[1] 陈强[1] 何宗钊[1] 许雪霞[1] 

机构地区：[1]青海省人民医院重症医学科,青海西宁810007

出　　处：《中华中医药学刊》2016年第12期3030-3032,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：青海省自然科学基金项目(2013-Z-921)

摘　　要：目的:探讨乌司他丁联合血必净治疗高原地区与平原地区感染性休克的效果对比分析。方法:选取2014年3月—2016年5月医院收治的高原地区感染性休克患者42例为观察组,另选取同时期平原地区感染性休克患者39例为对照组,两组患者均给予乌司他丁联合血必净治疗,对比两组患者临床疗效、治疗前后PICCO测量数据:心排血指数(CI)、心输出量(CO)、血管外肺水指数(EVLWI)、体循环阻力(SVR)变化,并对比治疗前后患者白介素-6(IL-6)、降钙素原(PCT)、脑型利钠肽(BNP)水平变化。结果:观察组总有效率为59.52%,对照组患者总有效率为84.62%,与对照组对比,观察组总有效率显著降低(P<0.05);与治疗前对比,观察组与对照组患者的CI、CO、EVLWI均明显降低,SVR明显升高,且对照组患者的CI、CO、EVLWI及SVR改善程度优于观察组(P<0.05);与治疗前对比,观察组与对照组的IL-6、PCT及BNP水平均显著降低,且对照组患者的IL-6、PCT及BNP降低水平较观察组变化更显著(P<0.05)。结论:乌司他丁联合血必净治疗平原地区感染性休克的效果优于治疗高原地区感染性休克患者。Objective：Comparatively analyze to explore the effect of ulinastatin combined with Xuebijing Injection on infectious shock in plateau area and flat area.Methods： A total of 42 cases of infection in plateau area from March 2014 to May 2016 in our hospital were selected for the observation group.During the same period,39 caseswith infectious shock in flat area were as the control group.Two groups＇ patients were treated with ulinastatin combined with Xuebijing Injection treatment,comparing two groups＇ clinical curative effect before and after treatment,cardiac index measurement PICCO index（CI）,cardiac output（CO）,extravascular lung water index（EVLWI）,systemic vascular resistance（SVR）changesand interleukin-6（IL-6）,procalcitonin（PCT） and brain natriuretic peptide（BNP） levels changes.Results：The total efficiency of the observation group was 59.52% and that of the control group was 84.62%.Compared with the control group,the total efficiency of the observation group decreased significantly（P〈0.05）.Compared with those before treatment,the observation group and the control group＇s CI,CO and EVLWI were significantly decreased and SVR increased significantly,and the control group＇s CI CO,EVLWIand SVR were better than those of the observation group（P〈0.05）.Compared with those before treatment,the observation group and control group＇s IL-6,PCT and BNP levels were significantly decreasedand the control group＇s IL-6,PCT and BNP levels were more significant than those of the observationgroup（P〈0.05）.Conclusion： Combined effect of ulinastatin and Xuebijing Injection on patients with infectious shock in flat area is better than on the patients in highlands.

关 键 词：乌司他丁 血必净 感染性休克 高原地区 平原地区 

分 类 号：R541.64[医药卫生—心血管疾病]