中重度子宫内膜异位症患者应用坤泰胶囊联合GnRH-a疗效及预后分析  

Clinical and Prognostic Analysis of Severe Endometriosis Patients Treated with Kuntai Capsule Combined with GnRH-a Therapy

作　　者：钟伟青[1] 钱红燕[2] 

机构地区：[1]杭州市萧山区第三人民医院妇产科,浙江萧山311251 [2]浙江萧山医院妇产科,浙江萧山311251

出　　处：《中华中医药学刊》2016年第12期3069-3072,共4页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:探讨坤泰胶囊联合Gn RH-a治疗40例中重度子宫内膜异位症患者的临床疗效以及对预后进行分析。方法:选取2013年2月—2015年8月在医院经手术证实的中重度子宫内膜异位症患者40例,采用随机数表法分为观察组和对照组各20例,对照组给予Gn RH-a治疗,观察组给予坤泰胶囊联合Gn RH-a治疗,比较两组患者治疗后性激素水平变化情况、治疗前后Kuppeman评分以及VAS评分变化情况、主要绝经期症状发生率情况以及治疗后临床疗效情况。结果:治疗前两组患者的性激素水平比较差异无统计学意义(P>0.05),治疗后,两组患者的E2、LH以及FSH都有所下降,但观察组(54.12±5.45)pmol/L、(2.78±0.14)U/L、(3.12±0.21)U/L低于对照组(70.56±9.78)pmol/L、(3.78±0.54)U/L、(4.98±0.10)U/L,两组比较差异显著(P<0.05);治疗后,两组患者的Kuppeman评分都有所上升,观察组(12.45±3.12)分高于对照组(8.45±2.98)分,两组患者的VAS评分都有所降低,观察组(3.12±0.12)分低于对照组(4.98±0.23)分,两组比较差异显著(P<0.05);观察组患者潮热、情绪波动、乏力、阴道干涩、骨痛以及睡眠障碍发生率低于对照组,两组患者治疗差异显著(P<0.05);观察组患者治疗后的总缓解率为95.00%高于对照组患者70.00%,两组患者比较差异显著(P<0.05)。结论:坤泰胶囊联合Gn RH-a治疗中重度子宫内膜异位症,可有效减轻Gn RH-a引起的部分雌激素低落症状,临床效果显著。Objective：To investigate the clinical efficacy of Kuntai Capsule combined with Gn RH-a of 40 cases of severe endometriosis treatment and the prognosis of patients was analyzed.Methods：Forty cases of moderate to severe endometriosis patients were selected from February 2013 to August 2015 in our hospital confirmed by surgery.By using a random number table method,the patients were divided into the observation group and the control group.Twenty patients in the control group were given Gn RH-a treatment and the observation group used Kuntai Capsule combined with Gn RH-a therapy.The hormone level changes,Kuppeman score and VAS score changes before and after treatment,the main symptoms of menopause as well as the incidence of clinical efficacy of treatment were compared between the two groups.Results：The sex hormone levels before treatment between the two groups was not statistically significant（P〈0.05）.After treatment,both groups E2,LH and FSH declined,but the observation group＇s [（54.12 ± 5.45）pmol/L,（2.78 ± 0.14）U/L,（3.12 ± 0.21） U/L] were lower than the control group＇s[（70.56 ± 9.78） pmol/L,（3.78 ± 0.54） U/L,（4.98 ±0.10） U/L] and the difference was significant（P〈0.05）.After treatment,both groups＇ Kuppeman rates increased.The observation group＇s（12.45 ± 3.12 points） was higher than that（8.45 ± 2.98 points） of the control group.Both groups＇ VAS score decreased.The observation group＇s（3.12 ± 0.12 points） was lower than the control group＇s（4.98± 0.23 points） and the difference was significant（P〈0.05）.The observation group＇s incidence of hot flashes,mood swings,fatigue,vaginal dryness,bone pain and sleep disorders,was lower than the control group＇s and the two groups were significant（P〈0.05）.The observation group＇s overall response rate after treatment was 95.00%,higher than 70.00%of the control group.There was a significant difference between the two groups（P〈0.05）.Conclusion：Kuntai Capsule combined with GnR H-a

关 键 词：坤泰胶囊 子宫内膜异位症 GnRH-a治疗 

分 类 号：R711.11[医药卫生—妇产科学]