CX3CL1和CX3CR1与动脉粥样硬化性心脏病损伤机制的研究现状  

CX3CL1 and CX3CR1 in lesion mechanism of atherosclerotic heart diseases

作　　者：李永姝[1] 张宝欢[2] 贾克刚[1] 刘军锋[1] 

机构地区：[1]中国医学科学院北京协和医学院泰达国际心血管病医院检验科,天津300457 [2]天津医科大学医学检验学院,天津300203

出　　处：《检验医学》2016年第11期1002-1010,共9页Laboratory Medicine

基　　金：天津市卫生局科技基金(2012KZ008);天津市滨海新区卫生局科技基金(2014BWKY001)

摘　　要：趋化因子Fractalkine(CX3CL1)及其特异性受体CX3C趋化因子受体1(CX3CR1)、CX3CL1-CX3CR1轴均参与了动脉粥样硬化的形成和发展,并改变了斑块成分和斑块的稳定性。CX3CR1 V249I和CX3CR1 T280M与冠状动脉损伤相关。在动脉粥样硬化斑块中,CX3CL1、CX3CR1通过血管平滑肌细胞(VSMC)和单核细胞/巨噬细胞进行表达,VSMC和单核细胞间相互作用需通过CX3CL1-CX3CR1轴,这种相互作用调节了单核细胞的生存及分化。抵抗素可能通过一系列涉及核因子-κB(NF-κB)、活化蛋白-1(AP-1)、信号转导和转录激活因子(STAT)1/STAT3的机制使CX3CL1和CX3CR1表达上调,进而产生平滑肌细胞的促炎性状态。在不稳定性冠心病及冠状动脉严重病变患者中,血清CX3CL1水平明显升高;血清CX3CR1在冠状动脉狭窄性疾病患者中明显升高,但与冠状动脉狭窄程度无相关性。通过CX3CL1/CX3CR1的相关研究,可揭示某些炎性介质在动脉粥样硬化性心脏病中的潜在机制和致病作用,从而为临床治疗策略及干预药物的研究提供依据及方向。Fractalkine（CX3CL1） and its specific receptor CX3C chemokine receptor1（CX3CR1）, CX3CL1-CX3CR1 axis are all involved in the formation and development of atherosclerosis,which change the plaque composition and stability of plaques. CX3CR1 V249I and CX3CR1 T280M are associated with coronary artery lesions. In atherosclerotic plaque,CX3CL1 and CX3CR1 were expressed by vascular smooth muscle cells（VSMC） and monocytes/macrophages. Interaction between vascular smooth muscle cells（VSMC） and monocyte needs CX3CL1-CX3CR1 axis,and this mutual effect regulates the survival and differentiation of monocyte. Through a series of mechanism,such as involved nuclear factor-kappa B（NF-κB）,activated protein-1（AP-1） and signal transducers and activators of transcription（STAT） 1/STAT3,resistin up-regulates the expressions of CX3CL1 and CX3CR1, and generates pro-inflammatory state of smooth muscle cells. Serum CX3CL1 level is increased in patients with unstable coronary artery diseases and patients with severe coronary artery lesions. Serum CX3CR1 level is increased in patients with coronary artery stenosis,which is not associated with the degree of coronary artery stenosis. The related study on CX3CL1/CX3CR1 shows the potential mechanism and pathogenicity effect of some inflammatory mediators in atherosclerotic heart diseases,so as to provide a reference for clinical treatment strategies and drug intervention studies.

关 键 词：FRACTALKINE CX3C趋化因子受体1 动脉粥样硬化 冠心病 单核细胞 

分 类 号：R446.1[医药卫生—诊断学]