广东省2008～2015年手足口病流行病学特征及病原学监测分析  

Epidemiology Characteristics and Pathogen Surveillance of Hand,Foot and Mouth Disease in Guangdong Province,China,2008～2015

作　　者：冀天娇[1] 谭小华[2] 刘冷[2] 顾新蕊 刘俐[1] 郑焕英[2] 曾汉日[2] 杨倩[1] 李晖[2] 许文波[1] 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所卫生部医学病毒病重点实验室,北京102206 [2]广东省疾病预防控制中心,广州516500

出　　处：《病毒学报》2016年第6期713-720,共8页Chinese Journal of Virology

基　　金：国家科技重大专项(项目号:2013ZX10004-202);题目:病毒性传染病病原谱流行规律及变异研究

摘　　要：为阐明广东省手足口病（Hand,foot,and mouth disease,HFMD）的流行病学特征及病原学构成,探索全省HFMD发病风险变化的趋势。本研究利用广东省2008-2015年HFMD监测数据、人口数据和地理资料,采用描述流行病学方法,对全省的HFMD发病趋势、人群分布特征以及病原构成等进行了系统分析。结果显示：广东省2008-2015HFMD报告人数2 133 722,重症人数5 066,死亡人数259;各地市均有不同严重程度的病例报道,尤以珠三角区域为重点高发区域;发病曲线呈双峰分布,春夏季是主高峰,秋季是次高峰;5岁以下儿童在全部发病人群、重症及死亡病例中比例分别为90.58%、95.93%和97.30%,其中3岁以下年龄组分别占65.24%、77.32%和81.85%;男性高发于女性。不同年份和不同季节的优势病原呈现动态变化,2009年主要以CV-A16流行为主;2013和2015年以非EV-A71非CV-A16其他肠道病毒为主,特别是2015年,其他EV占71.97%;但EV-A71一直是导致广东省重症病例和死亡病例的优势病原和绝对优势病原。本研究提示应继续加强广东省HFMD流行病和实验室监测,为广东省进一步完善HFMD防控策略提供科学数据支持。To understand the epidemiological etiology characteristics of hand,foot and mouth disease（HFMD）in Guangdong province,and to explore the risk change trend of the whole province.By using the descriptive epidemiological methods,the whole province＇s incidence trend,population distribution and pathogenic form of HFMD were analyzed with the HFMD surveillance data,population data and geographic information of Guangdong province from 2008 to 2015.The analysis results show：A total of 2,133,722 cases of HFMD,including 5,066 severe cases and 259 death cases were reported in Guangdong province from 2008 to 2015.All the cities of Guangdong had HFMD cases,especially the Pearl River DeltaRegions,which were on high-risk areas.There were two peaks every year,with the main peak of incidence occurred in spring and summer,and the sub peak occurred in autumn.Most cases were children aged5years old,the proportion of this group in overall infections,the severe and death cases were 90.58%,95.93%and 97.30%,respectively,while the proportion for the children less than 3years old were 77.32% and 81.85%,respectively.The incidence of this disease among men was higher than that of women.Dynamic changes were presented between different years and seasons：CV-A16 was more popular in 2009,and enterovirus that none EV-A71 and none CV-A16 were predominant strains in 2013 and 2015.Especially in 2015,the proportion of other EV ranged as high as 71.97%.Besides,EV-A71 was the absolute predominance pathogen within death cases and was important pathogen in severe cases.This study suggests that HFMD epidemiology and laboratory monitoring in Guangdong Province should be strengthened,and provides scientific data support for further improvement of HFMD prevention and control strategies in Guangdong Province.

关 键 词：手足口病 流行病学特征 病原学监测 广东省 

分 类 号：R373.2[医药卫生—病原生物学]