维生素D在类风湿关节炎中的作用及其研究进展  

The role of vitamin D in rheumatoid arthritis

作　　者：谢荣华[1] 郑朝晖[1] 朱平[1] 

机构地区：[1]第四军医大学西京医院,临床免疫科,全军风湿免疫专科研究所,西安710032

出　　处：《中国医师杂志》2016年第11期1744-1747,共4页Journal of Chinese Physician

摘　　要：维生素D缺乏在普通人群包括类风湿关节炎（RA）患者中非常普遍。维生素D通过自分泌调节重要的免疫学反应，维生素D缺乏可能与包括RA在内的多种疾病的发病有关。维生素D调节固有免疫和获得性免疫，对固有免疫的调节作用主要是通过Toll样受体进行，对获得性免疫的调节作用主要是通过T细胞分化尤其是辅助T细胞17（Th17）进行。由于Th17在RA的发病中非常重要，那么维生素D缺乏会对RA产生什么样的影响呢？许多研究表明维生素D缺乏与RA疾病活动的关系，但是结果不尽一致。笔者将阐述维生素D在RA中的免疫调节作用、维生素D缺乏在RA疾病活动、骨质疏松以及心血管病风险等方面的作用及其研究进展。Vitamin D deficiency is highly prevalent in the general population including rheumatoid arthritis （RA） patients. Autocrine regulation of vitamin D modulates important immune response. Vitamin D deficiency may be involved in the pathogenesis of many autoimmune diseases including RA. Vitamin D regulates both the innate and adaptive immune responses. Vitamin D＇s effects on the innate immune system are mainly through the toll-like receptor and on the adaptive immune system through T cell differentiation, particularly the Helper T cell （Th） 17 response. As Thl7 ceils are critical in the pathogenesis in RA, what effect will vitamin D deficiency lead to on the RA？ Many data have indicated the relationship between vitamin D deficiency and RA disease activities, but not all the results are consistent. Here, we review the immune-modulatory roles of vitamin D and its effects on disease activity, osteoporosis and cardiovascular disease risk in RA.

关 键 词：维生素D 维生素D缺乏 关节炎 类风湿 综述 

分 类 号：R593.22[医药卫生—内科学]